Measurement of liver T₁ and T₂ relaxation times in an experimental mouse model of liver fibrosis

Journal of Magnetic Resonance Imaging : JMRI
April M ChowEd X Wu

Abstract

To characterize changes in relaxation times of liver using quantitative magnetic resonance imaging (MRI) in an experimental mouse model of liver fibrosis. Quantitative MRI is a potentially robust method to characterize liver fibrosis. However, correlation between relaxation times and fibrosis stage has been controversial. Liver fibrosis was induced in male adult C57BL/6N mice (22-25 g; n = 12) by repetitive dosing of carbon tetrachloride (CCl(4) ). The animals were examined with a series of spin-echo (SE) images with varying TRs and multiecho SE imaging sequence at 7 T before and 2, 4, 6, and 8 weeks after CCl(4) insult. Hepatic T(1) and T(2) values were measured. Histology was performed with hematoxylin-eosin staining and Masson's trichrome staining. Significant increase (P < 0.001) in hepatic T(1) was found at 2, 4, 6, and 8 weeks following CCl(4) insult as compared with that before insult. Meanwhile, hepatic T(2) at 2, 4, 6, and 8 weeks after CCl(4) insult was significantly higher (P < 0.001) than that before the insult. Liver histology showed collagen deposition, edema, and infiltration of inflammatory cells in livers with CCl(4) insult. Both longitudinal and transverse relaxation times may serve as robust markers for liver...Continue Reading

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Citations

Sep 4, 2015·European Radiology·Shu-Zhong ChenYì-Xiáng J Wáng
Nov 19, 2013·Journal of Magnetic Resonance Imaging : JMRI·Jens-Peter KühnScott Reeder
Aug 13, 2015·Journal of Magnetic Resonance Imaging : JMRI·Zhiming LiXiaoming Yang
Aug 17, 2016·Journal of Magnetic Resonance Imaging : JMRI·Hui ZhangHua Guo
Aug 11, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christian E AndersonChris A Flask
Oct 17, 2017·Journal of Magnetic Resonance Imaging : JMRI·Hiroyuki MorisakaHiroshi Onishi
Mar 4, 2018·Abdominal Radiology·Isabel KazourRobert J Fleck
Nov 22, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Iris Y ZhouEd X Wu
Feb 23, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Thibaut L FallerEmeline J Ribot
Sep 24, 2015·PLoS Neglected Tropical Diseases·Brice MasiAngèle Viola
Dec 17, 2016·Journal of Magnetic Resonance Imaging : JMRI·Léonie PetitclercAn Tang
Jun 24, 2017·Journal of Magnetic Resonance Imaging : JMRI·Sami AlghamdiYasvir A Tesiram
Sep 24, 2016·Journal of Magnetic Resonance Imaging : JMRI·Hiroyuki MorisakaHiroshi Onishi
Mar 20, 2021·Journal of Magnetic Resonance Imaging : JMRI·Diana M LindquistJonathan R Dillman
Jun 27, 2020·Current Medical Imaging·Lianjun LanJian Shu

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