Measurement of nasal irritant sensitivity to pulsed carbon dioxide: a pilot study

Archives of Environmental Health
D Shusterman, John Balmes

Abstract

Nasal irritation and associated symptoms (e.g., nasal congestion, rhinorrhea, sinus headache) are important air-pollution-related health complaints, particularly in so-called problem buildings. Individual differences in nasal irritant sensitivity are therefore of both clinical and regulatory interest. To document such differences, one must first functionally define perceptual acuity to airborne irritants. In an adaptation of an established sensory testing method, the authors used the odorless irritant carbon dioxide in an electronically controlled dilution apparatus to deliver brief (approximately 3 s) pulses at controlled levels (10%-70%, vol/vol), synchronized with the inspiratory phase of the respiratory cycle. Investigators who use this apparatus can use a variant of the forced-choice paradigm for threshold determination to document nasal irritant sensitivity. The authors recruited 30 adult volunteers (17 males, 13 females; average age = 41 y, range = 19-79 y) from a university laboratory complex and from the general community. Within this group, there was a skewed distribution of carbon dioxide thresholds (arithmetic mean = 28%, geometric mean = 27% [vol/vol]). In univariate analyses, geometric mean carbon dioxide threshol...Continue Reading

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Citations

Mar 1, 2012·International Archives of Occupational and Environmental Health·Joerg U MuellerGerhard Triebig
Mar 29, 2002·Current Allergy and Asthma Reports·Wytske J Fokkens
Mar 5, 2005·The Journal of Allergy and Clinical Immunology·Robert A NathanAlkis Togias
Jul 2, 1998·The Journal of Allergy and Clinical Immunology·D J ShustermanJ R Balmes
May 28, 2003·Journal of Clinical Epidemiology·Angela ZacharasiewiczNeil Pearce
Apr 18, 2003·Perception & Psychophysics·Charles J WysockiTomas Radil
Apr 29, 2004·Critical Reviews in Toxicology·Richard L DotyMichael Hodgson
Jan 24, 2007·Regulatory Toxicology and Pharmacology : RTP·Gunnar Damgård NielsenYves Alarie
Nov 4, 2005·Allergy·J B van RijswijkW J Fokkens
Aug 20, 2005·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Johan N LundströmThomas Hummel
Apr 12, 2013·The Journal of Headache and Pain·Tim P JürgensArne May

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