Measurement of panic-like responses following intravenous infusion of sodium lactate in panic-prone rats

Current Protocols in Neuroscience
T J SajdykA Shekhar

Abstract

This unit describes a putative animal model for panic disorder. The basic premise is that pharmacological disruption of critical brain regions implicated in the circuitry of anxiety will lead to a condition similar to that of the human disorder. A clinically relevant test, the sodium lactate challenge, is utilized to assess parallels between the human condition and this rat model.

References

Jun 1, 1989·Archives of General Psychiatry·E M ReimanK A Hackman
Jul 1, 1987·Brain Research·L L Bernardis, L L Bellinger
Apr 1, 1986·The American Journal of Psychiatry·M R LiebowitzD F Klein
Dec 21, 1967·The New England Journal of Medicine·F N Pitts, J N McClure
Feb 1, 1995·Pharmacology, Biochemistry, and Behavior·A Shekhar, J S Katner
Oct 1, 1996·Pharmacology, Biochemistry, and Behavior·A ShekharW J McBride
Jul 23, 1999·Annals of the New York Academy of Sciences·A ShekharS K Sanders

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Citations

Apr 19, 2012·Depression and Anxiety·Nina C DonnerChristopher A Lowry

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