Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases in patients with primary aldosteronism

Hypertension
Fumitoshi SatohSadayoshi Ito

Abstract

Adrenal venous sampling is currently the only reliable method to distinguish unilateral from bilateral diseases in primary aldosteronism. In this study, we attempted to determine whether peripheral plasma levels of 18-oxocortisol (18oxoF) and 18-hydroxycortisol could contribute to the clinical differentiation between aldosteronoma and bilateral hyperaldosteronism in 234 patients with primary aldosteronism, including computed tomography (CT)-detectable aldosteronoma (n=113) and bilateral hyperaldosteronism (n=121), all of whom underwent CT and adrenal venous sampling. All aldosteronomas were surgically resected and the accuracy of diagnosis was clinically and histopathologically confirmed. 18oxoF and 18-hydroxycortisol were measured using liquid chromatography tandem mass spectrometry. Receiver operating characteristic analysis of 18oxoF discrimination of adenoma from hyperplasia demonstrated sensitivity/specificity of 0.83/0.99 at a cut-off value of 4.7 ng/dL, compared with that based on 18-hydroxycortisol (sensitivity/specificity: 0.62/0.96). 18oxoF levels above 6.1 ng/dL or of aldosterone >32.7 ng/dL were found in 95 of 113 patients with aldosteronoma (84%) but in none of 121 bilateral hyperaldosteronism, 30 of whom harbored ...Continue Reading

References

Apr 1, 1993·The Journal of Clinical Endocrinology and Metabolism·S UlickE D Vaughan
Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·M StowasserR D Gordon
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Paolo MulateroWilliam F Young
May 12, 2004·Molecular and Cellular Endocrinology·Michael Stowasser, Richard D Gordon
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·E Marie FreelJohn M C Connell
Jan 20, 2005·Surgery·William F YoungJon A van Heerden
Apr 20, 2005·Journal of the American College of Cardiology·Paul MilliezJean-Jacques Mourad
Mar 10, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masao OmuraTetsuo Nishikawa
Feb 6, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Fumitoshi SatohSadayoshi Ito
Jun 17, 2008·The Journal of Clinical Endocrinology and Metabolism·John W FunderUNKNOWN Endocrine Society
Jul 24, 2008·AJR. American Journal of Roentgenology·Tomonori MatsuuraShoki Takahashi
May 20, 2011·The Journal of Clinical Endocrinology and Metabolism·Yasuhiro NakamuraSadayoshi Ito
Jul 2, 2011·Journal of Hypertension·Francesco FalloPaolo Mulatero
Aug 11, 2011·Endocrine Journal·Tetsuo NishikawaUNKNOWN Task Force Committee on Primary Aldosteronism, The Japan Endocrine Society
Jan 13, 2012·The Journal of Clinical Endocrinology and Metabolism·Paolo MulateroFranco Veglio
Mar 9, 2012·The Journal of Clinical Endocrinology and Metabolism·Gian Paolo RossiAchille Cesare Pessina
Dec 12, 2013·Molecular and Cellular Endocrinology·Celso E Gomez-SanchezElise P Gomez-Sanchez

❮ Previous
Next ❯

Citations

Oct 16, 2015·Journal of Cardiovascular Pharmacology·Elise Gomez-Sanchez
Nov 11, 2015·Journal of the American Society of Hypertension : JASH·David H Ellison
Apr 28, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Olivier Steichen, Laurence Amar
Apr 28, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Celso E Gomez-Sanchez, Elise P Gomez-Sanchez
May 2, 2016·Clinical Biochemistry·Brian G Keevil
May 4, 2016·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Valentina CrudoPaolo Mulatero
Oct 18, 2016·Clinical Endocrinology·Christoph DegenhartFelix Beuschlein
Nov 18, 2016·The Tohoku Journal of Experimental Medicine·Yasuhiro NakamuraHironobu Sasano
May 10, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Graeme EisenhoferStefan R Bornstein
Apr 20, 2017·International Journal of Molecular Sciences·Fabrizio BuffoloPaolo Mulatero
Mar 14, 2018·American Journal of Hypertension·Ryo MorimotoFumitoshi Satoh
Sep 15, 2017·European Journal of Endocrinology·Jacques W M LendersCelso E Gomez-Sanchez
Feb 15, 2017·Hypertension·Laurence AmarAurelien Lorthioir
Nov 18, 2015·Hypertension·Tracy Ann WilliamsMartin Reincke
Jun 28, 2017·Hypertension·Ryo MorimotoFumitoshi Satoh
Aug 8, 2018·The Journal of Clinical Endocrinology and Metabolism·Kazutaka NanbaWilliam E Rainey
Mar 21, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Flaminia Fanelli, Guido Di Dalmazi
May 7, 2020·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Satoshi KidoguchiTakashi Yokoo
Mar 5, 2016·The Journal of Clinical Endocrinology and Metabolism·John W FunderWilliam F Young
Aug 28, 2020·The Journal of Clinical Endocrinology and Metabolism·Kazutaka NanbaHironobu Sasano
Mar 24, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Anand VaidyaUNKNOWN AACE Adrenal Scientific Committee
Apr 29, 2020·Journal of Human Hypertension·Renata LibiantoJun Yang
Oct 26, 2018·Circulation·James Brian ByrdRichard J Auchus
Dec 21, 2018·Reviews in Endocrine & Metabolic Disorders·Natividad Pons FernándezFernando Calvo
Aug 14, 2019·The Journal of Clinical Endocrinology and Metabolism·Taweesak WannachaleeAdina F Turcu
Jan 1, 2021·The Journal of Clinical Endocrinology and Metabolism·Adina F Turcu, Richard Auchus
Dec 16, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Yuhong YangTracy Ann Williams
Mar 16, 2021·The Tohoku Journal of Experimental Medicine·Man Ho Choi
May 1, 2021·Biomedicines·Kiyotaka ItchoMasayasu Yoneda
Jun 1, 2021·Case Reports in Urology·Jean SossaFelix Atadokpede
Jun 13, 2021·The Journal of Clinical Endocrinology and Metabolism·Yuta TezukaAdina F Turcu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.