Measurement of PGH synthase activity using a pan-specific monoclonal antibody

Prostaglandins, Leukotrienes, and Essential Fatty Acids
E R HallK F Frasier-Scott

Abstract

A pan-specific monoclonal antibody that recognizes a variety of prostaglandin moieties and does not recognize arachidonic acid or the hydroxy-eicosatetraenoic acids was used to assess the general ability of a tissue to produce prostaglandins. Although this assay does not give a quantitative measure of PGH synthase activity, it does provide a sensitive and convenient means of screening a large number of samples for prostaglandin production.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·F A Fitzpatrick, D A Stringfellow
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·O J PlesciaK Grinwich
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·A M Fulton, J G Levy

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Citations

Aug 30, 2000·Prostaglandins & Other Lipid Mediators·A Tsai, R J Kulmacz

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