PMID: 1983147Dec 1, 1990

Measurement of protein synthesis by the phenylalanine flooding dose technique: effect of phenylalanine and anaesthesia on plasma electrolyte, enzyme and metabolite levels

The Journal of Pharmacy and Pharmacology
V R PreedyT J Peters

Abstract

Ten minutes after an intravenous flooding dose of phenylalanine to rats, plasma sodium and calcium concentrations were slightly reduced (by 2-7%) but no effects on potassium or phosphate were observed. Creatine kinase activities were significantly increased by phenylalanine injection (by 39%), but alkaline phosphatase, alanine aminotransferase, lactate dehydrogenase and aspartate aminotransferase activities were unaltered. Plasma concentrations of total proteins, albumin, cholesterol, triglycerides, urea, creatinine and glucose were also unaffected. In the presence of anaesthesia, phenylalanine injection had almost identical effects, although the increase in creatine kinase activities did not reach statistical significance. Anaesthesia for 10 min reduced plasma potassium concentrations (by 27%), and calcium (by 5%), though phosphate and sodium were unaltered. The activities of lactate dehydrogenase, creatine kinase and aspartate aminotransferase were reduced by between 36-52%, but alkaline phosphatase and alanine aminotransferase activities were unaltered by anaesthesia. Plasma concentrations of total proteins and albumin were also reduced (both by 9%), but glucose concentrations were increased (by 33%). Anaesthesia had no othe...Continue Reading

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Citations

Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·V L SchultzS U Toverud
Feb 1, 1993·Amino Acids·A L Schaefer, S L Scott
Jan 1, 1996·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·C J WaterfieldJ A Timbrell
Oct 7, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M L KowalskiM Mis

Related Concepts

SGPT - Glutamate pyruvate transaminase
SGOT - Glutamate oxaloacetate transaminase
Blood
Serum Proteins
Calcium
Macro-Creatine Kinase
Drug Interactions
Intravenous Injections
Anecotan
Endorphenyl

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