PMID: 8941527Nov 1, 1996Paper

Measurement of pulmonary blood flow by fractal analysis of flow heterogeneity in isolated canine lungs

Journal of Applied Physiology
S A BarmanI C Ehrhart

Abstract

Regional heterogeneity of lung blood flow can be measured by analyzing the relative dispersion (RD) of mass (weight)-flow data. Numerous studies have shown that pulmonary blood flow is fractal in nature, a phenomenon that can be characterized by the fractal dimension and the RD for the smallest realizable volume element (piece size). Although information exists for the applicability of fractal analysis to pulmonary blood flow in whole animal models, little is known in isolated organs. Therefore, the present study was done to determine the effect of blood flow rate on the distribution of pulmonary blood flow in the isolated blood-perfused canine lung lobe by using fractal analysis. Four different radiolabeled microspheres (141Ce, 95Nb, 85Sr, and 51Cr), each 15 microns in diameter, were injected into the pulmonary lobar artery of isolated canine lung lobes (n = 5) perfused at four different flow rates (flow 1 = 0.42 +/- 0.02 l/min; flow 2 = 1.12 +/- 0.07 l/min; flow 3 = 2.25 +/- 0.17 l/min; flow 4 = 2.59 +/- 0.17 l/min), and the pulmonary blood flow distribution was measured. The results of the present study indicate that under isogravimetric blood flow conditions, all regions of horizontally perfused isolated lung lobes received...Continue Reading

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Citations

Mar 5, 1998·The American Journal of Physiology·M KleenK Messmer
Sep 8, 1997·European Journal of Nuclear Medicine·J T KuikkaP Räsänen
Aug 5, 2000·Journal of Applied Physiology·M A ChornukM P Hlastala
Apr 7, 1999·Acta Physiologica Scandinavica·M N MelsomG Nicolaysen
Apr 6, 2000·Journal of Applied Physiology·J G Venegas, G G Galletti
Aug 31, 2002·Journal of Theoretical Biology·Wayne Kendal

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