Measurement of pulsatile total blood flow in the human and rat retina with ultrahigh speed spectral/Fourier domain OCT.

Biomedical Optics Express
Woojhon ChoiJames G Fujimoto

Abstract

We present an approach to measure pulsatile total retinal arterial blood flow in humans and rats using ultrahigh speed Doppler OCT. The axial blood velocity is measured in an en face plane by raster scanning and the flow is calculated by integrating over the vessel area, without the need to measure the Doppler angle. By measuring flow at the central retinal artery, the scan area can be very small. Combined with ultrahigh speed, this approach enables high volume acquisition rates necessary for pulsatile total flow measurement without modification in the OCT system optics. A spectral domain OCT system at 840nm with an axial scan rate of 244kHz was used for this study. At 244kHz the nominal axial velocity range that could be measured without phase wrapping was ±37.7mm/s. By repeatedly scanning a small area centered at the central retinal artery with high volume acquisition rates, pulsatile flow characteristics, such as systolic, diastolic, and mean total flow values, were measured. Real-time Doppler C-scan preview is proposed as a guidance tool to enable quick and easy alignment necessary for large scale studies. Data processing for flow calculation can be entirely automatic using this approach because of the simple and robust alg...Continue Reading

References

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Jan 25, 2011·Biomedical Optics Express·Amardeep S G SinghRainer A Leitgeb
Mar 18, 2011·Biomedical Optics Express·Zhongwei ZhiRuikang K Wang
Jun 24, 2011·Biomedical Optics Express·Bernhard BaumannJames G Fujimoto
Aug 13, 2011·Biomedical Optics Express·Hansford C HendargoJoseph A Izatt

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Citations

Jun 4, 2014·Current Eye Research·Doreen SchmidlAlina Popa-Cherecheanu
Nov 20, 2012·Biomedical Optics Express·Zhongwei ZhiRuikang K Wang
Feb 28, 2014·Biomedical Optics Express·Lindsy M PetersonAndrew M Rollins
Feb 16, 2013·Biomedical Optics Express·Jonathan J LiuJames G Fujimoto
Jul 13, 2013·Biomedical Optics Express·Cedric BlatterRainer A Leitgeb
Apr 8, 2014·Progress in Retinal and Eye Research·Rainer A LeitgebLeopold Schmetterer
Nov 19, 2015·Scientific Reports·Brian T SoetiknoAmani A Fawzi
Jan 6, 2017·Journal of Biomedical Optics·Eric M MoultJames G Fujimoto
Jun 16, 2017·Journal of Biomedical Optics·Ruikang K WangShaozhen Song
Feb 14, 2018·The Journal of Pharmacology and Experimental Therapeutics·Keagan P CollinsDaniel L Gustafson
Aug 9, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hidaka TakakoNao-I Nobuhisa
Oct 21, 2014·Physics in Medicine and Biology·Siavash Yousefi, Ruikang K Wang
Nov 27, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yasushi WadaKazuhisa Sugiyama
May 30, 2019·Biomechanics and Modeling in Mechanobiology·Joseph RebhanBarry J Doyle

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