Measurement of real pulsatile blood flow using X-ray PIV technique with CO2 microbubbles

Scientific Reports
Hanwook ParkSang-Joon Lee

Abstract

Synchrotron X-ray imaging technique has been used to investigate biofluid flows in a non-destructive manner. This study aims to investigate the feasibility of the X-ray PIV technique with CO2 microbubbles as flow tracer for measurement of pulsatile blood flows under in vivo conditions. The traceability of CO2 microbubbles in a pulsatile flow was demonstrated through in vitro experiment. A rat extracorporeal bypass loop was used by connecting a tube between the abdominal aorta and jugular vein of a rat to obtain hemodynamic information of actual pulsatile blood flows without changing the hemorheological properties. The decrease in image contrast of the surrounding tissue was also investigated for in vivo applications of the proposed technique. This technique could be used to accurately measure whole velocity field information of real pulsatile blood flows and has strong potential for hemodynamic diagnosis of cardiovascular diseases.

References

Mar 1, 1995·AJR. American Journal of Roentgenology·S R Kerns, I F Hawkins
Dec 11, 1999·JAMA : the Journal of the American Medical Association·A M MalekS Izumo
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J J BishopP C Johnson
May 12, 2001·Chest·B W HolcombI M Robbins
Jan 2, 2004·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·E Stride, N Saffari
Sep 28, 2004·Physics in Medicine and Biology·R A Lewis
Sep 5, 2007·Echocardiography·Françoise ChristinBertrand Delafosse
Oct 2, 2007·Physiological Measurement·Jung Yeop LeeSang Joon Lee
Jul 8, 2008·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Shu-Ang Zhou, Anders Brahme
Oct 20, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Arash KheradvarDavid Sahn
Dec 22, 2009·Biosensors & Bioelectronics·Sang Joon LeeSungsook Ahn
Oct 26, 2010·Atherosclerosis·Emanuele CecchiLucia Mannini
Feb 5, 2011·Annals of Biomedical Engineering·R Aidan JamisonAndreas Fouras
Oct 6, 2011·Microvascular Research·Sang-Joon LeeKweon-Ho Nam
Feb 23, 2012·The International Journal of Cardiovascular Imaging·Sung Yong JungSang Joon Lee
Mar 6, 2012·Microvascular Research·Kweon-Ho NamSang Joon Lee
Apr 17, 2012·Physics in Medicine and Biology·U LundströmH M Hertz
Oct 3, 2012·PloS One·Christian PoelmaJerry Westerweel
Oct 25, 2012·Journal of Synchrotron Radiation·R A JamisonAndreas Fouras
Apr 18, 2013·Journal of Synchrotron Radiation·Sung Yong JungSang Joon Lee
May 30, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R LorenzM Markl
Sep 5, 2013·Clinical Hemorheology and Microcirculation·Eunseop Yeom, Sang Joon Lee
Oct 15, 2013·PloS One·R Aidan JamisonAndreas Fouras
Sep 2, 2014·Journal of Synchrotron Radiation·Sang Joon LeeSung Yong Jung

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
extracorporeal bypass

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.