Measurement of reticulocyte hemoglobin content to diagnose iron deficiency in Saudi children

European Journal of Pediatrics
Ahmad Fayez Bakr, Gale Sarette

Abstract

Iron deficiency and iron deficiency anemia are common conditions in children, especially in developing countries. It is often difficult for the pediatrician to know which indices should be used in the diagnosis of these conditions in children. Reticulocyte hemoglobin (Hb) content (CHr) has been shown to be an accurate indicator of anemia, however whether its use suits the situation in developing countries or not is unclear. The aim of this study was to evaluate the value and effectiveness of using CHr as a method to diagnose iron deficiency and iron deficiency anemia in Saudi children. The samples for the study were collected from 305 children suspected to have anemia. Complete blood count, transferrin saturation (Tfsat), ferritin, circulating transferrin receptor (TfR) and CHr were measured. Three groups were defined, iron deficiency (Tfsat <20%, Hb >11 g/dL; n=120), iron deficiency anemia (Tfsat <20%, Hb <11 g/dL; (n=73) and controls (Tfsat >20%; n=112). The anemic group had significantly lower macrocytic anemia (MCV), mean corpuscular hemoglobin (MCH) and CHr. All of the variables in the anemia group were significantly lower than those of the control group except for the ferritin level. Compared to the control group, the iro...Continue Reading

References

Mar 1, 1992·Journal of General Internal Medicine·G H GuyattC Patterson
May 1, 1992·The Medical Clinics of North America·A C Massey
Sep 5, 1991·The New England Journal of Medicine·B LozoffA W Wolf
Jul 15, 1993·The New England Journal of Medicine·F A Oski
Mar 26, 1997·JAMA : the Journal of the American Medical Association·A C LookerC L Johnson
Jun 22, 1999·JAMA : the Journal of the American Medical Association·C BrugnaraO Platt
Jun 19, 2002·European Journal of Haematology·Sanna KotisaariKari Punnonen

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Citations

Mar 26, 2008·Heart Failure Reviews·Garry J Handelman, Nathan W Levin
Mar 26, 2010·European Journal of Pediatrics·Giorgos L ChouliarasLilia Lycopoulou
Oct 6, 2015·Veterinary Clinical Pathology·Lauren B RadakovichChristine S Olver
Jun 13, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M E Mateos GonzálezA Nogales Espert
Dec 17, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sarka DavidkovaChanel Prestidge
Mar 22, 2018·Journal of Pediatric Hematology/oncology·María M Ibáñez-AlcaldeTesifón Parrón-Carreño
Nov 22, 2007·American Journal of Hematology·Alan E MastDennis J Dietzen
Aug 17, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sarah J HartPriya S Kishnani
Jul 13, 2016·Journal of Pediatric Hematology/oncology·Encarnación López-RuzafaManuel Martín-González
Oct 12, 2021·Medical Oncology·Mohammad A AlfhiliJawaher Alsughayyir

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