Measurement of Salivary Adrenal-Specific Androgens as Biomarkers of Therapy Control in 21-Hydroxylase Deficiency

The Journal of Clinical Endocrinology and Metabolism
Irina BacilaNils Krone

Abstract

Monitoring of hormonal control represents a key part of the management of congenital adrenal hyperplasia (CAH). Monitoring strategies remain suboptimal because they rely on frequent blood tests and are not specific for adrenal-derived hormones. Recent evidence suggests the crucial role of adrenal-specific 11-oxygenated-C19 androgens in the pathogenesis of CAH. To establish a correlation between plasma and salivary adrenal-specific androgens in CAH as a noninvasive monitoring strategy. This prospective cross-sectional study recruited patients between 2015 and 2018. Multicenter study including 13 tertiary centers in the United Kingdom. Seventy-eight children with CAH and 62 matched healthy controls. Using liquid chromatography-tandem mass spectrometry, plasma and salivary concentrations of five steroids were measured: 17-hydroxyprogesterone (17OHP), androstenedione (A4), testosterone (T), 11-hydroxyandrostenedione (11OHA4), and 11-ketotestosterone (11KT). The correlation between plasma and salivary steroids was analyzed to assess their use in clinical practice. Strong correlations between plasma and salivary steroid concentrations in patients with CAH were detected: 17OHP (rs = 0.871; P < 0.001), A4 (rs = 0.931; P < 0.001), T (rs...Continue Reading

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Jul 31, 2019·The Journal of Clinical Endocrinology and Metabolism·Irina BacilaNils Krone

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Citations

Sep 20, 2019·International Journal of Molecular Sciences·Federico BaronioAntonio Balsamo
Aug 9, 2020·The Journal of Clinical Endocrinology and Metabolism·Richard J Auchus
Nov 21, 2019·Clinical Endocrinology·Marianna MinnettiMartin O Savage
Jul 31, 2019·The Journal of Clinical Endocrinology and Metabolism·Irina BacilaNils Krone
Dec 6, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Jonanlis Ramirez Alcantara, Alyssa Halper
Jan 9, 2021·Frontiers in Pediatrics·Antonio BalsamoAlessandra Cassio
Jun 25, 2021·The Journal of Clinical Endocrinology and Metabolism·Hanna Franziska NowotnyNicole Reisch
May 8, 2021·Endocrine Reviews·Hedi L Claahsen-van der GrintenPerrin C White
Nov 18, 2021·The Journal of Clinical Endocrinology and Metabolism·Mariska A M SchröderHedi L Claahsen van der Grinten

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