Measurement of serum ferritin by radioimmunoassay: results in normal individuals and patients with breast cancer.

Journal of the National Cancer Institute
D M Marcus, N Zinberg

Abstract

Ferritins are iron-containing proteins found in normal tissues; they increase in concentration in many tumors and the blood of tumor-bearing individuals. We utilized a double-antibody radioimmunoassay for measurement of serum ferritin and defined the upper limit of normal as 146 ng/ml for women (mean 34 ng/ml) and 193 ng/ml for men (mean 93 ng/ml). Serum ferritin levels exceeded these limits in preoperative sera of 41% of women with mammary carcinoma (mean 199 ng/ml) and in 67% of women with locally recurrent or metastatic mammary carcinoma (mean 671 ng/ml). Individuals with hepatic inflammatory states are known to have high serum ferritin, and ferritin was increased in 43% of patients with hepatitis or cirrhosis (mean 364 ng/ml) and in 13% of patients with ulcerative colitis or gastroduodenal ulcers (mean 106 ng/ml). Measurement of serum ferritin may be useful in evaluation of patients with breast cancer and in monitoring their response to therapy.

Citations

Nov 1, 1976·Journal of Clinical Pathology·A M NevilleE Heyderman
Sep 1, 1978·Journal of Clinical Pathology·W M DeppeP Naidoo
Aug 1, 1977·Cancer·R C CoombesA M Neville
Nov 1, 1990·Breast Cancer Research and Treatment·M StiererC Moroz
Dec 1, 1989·Breast Cancer Research and Treatment·R E WeinsteinD R Pieper
Sep 15, 1986·Cancer·G Zandman-GoddardC Hershko
Apr 1, 1985·American Journal of Hematology·R BassanT Barbui
Nov 1, 1981·British Journal of Haematology·A M KonijnC Hershko
Feb 22, 2017·International Journal of Molecular Sciences·Sara PizzamiglioItalia Bongarzone
Jan 1, 1980·Journal of Surgical Oncology·J F PaoneJ H Shaper
Jan 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·M PagéM Nilsson
Aug 1, 1978·Journal of Clinical Pathology·M D BarnettD L Mollin
Dec 1, 1982·Cancer·R E WeinsteinB K Silberberg
Dec 15, 1983·Cancer·M H DörnerP Drings
Mar 1, 1982·Scandinavian Journal of Haematology·E JakobsenM Aas
Jan 5, 2001·Expert Opinion on Investigational Drugs·D R Richardson
Jul 1, 2006·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Hideo AsakawaSeiichi Takasaki
Jan 1, 1978·CRC Critical Reviews in Clinical Laboratory Sciences·C P Alfrey
Sep 1, 1981·Thorax·J M Shneerson, B M Jones
Feb 1, 1994·Journal of Gastroenterology·T KishidaM Kobayashi
Jan 1, 1978·American Journal of Hematology·S RyanW H Crosby
Aug 1, 1977·Scandinavian Journal of Haematology·M A SiimesP R Dallman
Nov 14, 2003·Journal of Clinical Laboratory Analysis·Nobuo KotajimaMasami Murakami
Aug 22, 2018·Annual Review of Nutrition·Suzy V TortiFrank M Torti
Apr 25, 2020·Frontiers in Oncology·Rikki A M BrownPeter J Leedman
May 1, 1984·Cancer·C CohenL R Budgeon
Jun 1, 1982·Critical Reviews in Clinical Laboratory Sciences·B E Statland, P Winkel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.