Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers

Pediatric Pulmonology
Andres CastilloRobert S Tepper

Abstract

We describe a method for measuring carbon monoxide diffusing capacity (DL(CO)) and alveolar volume (V(A)) in sleeping infants, using a single 4-sec breath-hold technique. The breath-hold maneuver is obtained by inducing a respiratory pause of the respiratory system. Several inflations of the respiratory system with room air to a lung volume with an airway pressure of 30 cmH2O (V30) inhibit inspiratory effort. The respiratory system is then inflated with a test gas containing helium and a stable isotope of carbon monoxide (C18O), and a respiratory pause is maintained for 4 sec and followed by passive expiration to functional residual capacity. Concentrations of helium and C18O are continuously measured with a mass spectrometer. Twelve healthy infants between 6-22 months of age were evaluated. For 9 of 12 subjects, duplicate measurements of alveolar volume at 30 cmH2O (V(A30)) and DL(CO) were within 10%, which are the recommendations for older children and adults. Among these 9 subjects, values of V(A30) and DL(CO) increased with increasing body length (r2 = 0.82 and 0.79, respectively). The remaining 3 subjects had two values within 10-15%. Measurement of V(A) and DL(CO) with the single breath-hold technique at an elevated lung ...Continue Reading

References

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Citations

Nov 11, 2008·American Journal of Respiratory and Critical Care Medicine·Juan E BalinottiRobert S Tepper
Feb 6, 2010·American Journal of Respiratory and Critical Care Medicine·Juan E BalinottiRobert S Tepper
Aug 8, 2014·Thorax·Peter J F M Merkus
Dec 3, 2014·Pediatric Pulmonology·Santiago J AssafRobert S Tepper
Sep 9, 2011·Pediatric Pulmonology·Valentina C ChakrRobert S Tepper
Nov 14, 2015·American Journal of Respiratory and Critical Care Medicine·Daniel V ChangRobert S Tepper
Mar 3, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shannon J SimpsonAndrew C Wilson
Dec 6, 2018·Annals of the American Thoracic Society·Laura Gochicoa-RangelLuis Torre-Bouscoulet
Jan 12, 2008·Journal of Applied Physiology·Ines BolleHolger Schulz
Jul 4, 2020·Pediatric Pulmonology·Anuja BandyopadhyayRobert S Tepper
Jul 24, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Astrid Madsen RingFrederik Buchvald
Dec 22, 2017·Pediatric Pulmonology·Eduardo L L PracaRobert S Tepper

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