PMID: 3748467Aug 15, 1986Paper

Measurement of stimulated dopamine release in the rat by in vivo voltammetry: the influence of stimulus duration on drug responses

Neuroscience Letters
J A StamfordJ Millar

Abstract

High-speed cyclic voltammetry at carbon fibre microelectrodes was used to monitor stimulated striatal dopamine (DA) release in the anaesthetised rat. The effects of metoclopramide, chlorpromazine, benztropine and dexamphetamine on DA release after 1 s and 10 s stimulations were investigated. The antagonists enhanced DA release most clearly with 1 s stimuli. Benztropine had no effect on DA release with the 10 s stimulations, but elevated release after 1 s trains. Dexamphetamine reduced release with 10 s stimuli but enhanced release after 1 s trains. The results are discussed in terms of neuronal DA uptake and releasable DA pool size.

References

Jan 1, 1977·British Journal of Clinical Pharmacology·U SchachtG Bäcker
Jan 11, 1979·Nature·J W Kebabian, D B Calne
Oct 1, 1979·Journal of Neuroscience Methods·M Armstrong-James, J Millar
Sep 28, 1984·Neuroscience Letters·J A StamfordR M Wightman
Jun 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·T AlanderM Grabowska-Andén

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Citations

Jan 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·D P DaberkowM F Roitman
Feb 22, 2011·Behavioural Brain Research·Stephen M SiviyJohn P Walsh
Jan 26, 2012·Biomedical Chromatography : BMC·Lucía Asensi-BernardiMaría J Medina-Hernández

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