Measurement of striatal and extrastriatal dopamine D1 receptor binding potential with [11C]NNC 112 in humans: validation and reproducibility

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Anissa Abi-DarghamM Laruelle

Abstract

To evaluate the postulated role of extrastriatal D1 receptors in human cognition and psychopathology requires an accurate and reliable method for quantification of these receptors in the living human brain. [11C]NNC 112 is a promising novel radiotracer for positron emission tomography imaging of the D1 receptor. The goal of this study was to develop and evaluate methods to derive D1 receptor parameters in striatal and extrastriatal regions of the human brain with [11C]NNC 112. Six healthy volunteers were studied twice. Two methods of analysis (kinetic and graphical) were applied to 12 regions (neocortical, limbic, and subcortical regions) to derive four outcome measures: total distribution volume, distribution volume ratio, binding potential (BP), and specific-to-nonspecific equilibrium partition coefficient (k3/k4). Both kinetic and graphic analyses provided BP and k3/k4 values in good agreement with the known distribution of D1 receptors (striatum > limbic regions = neocortical regions > thalamus). The identifiability of outcome measures derived by kinetic analysis was excellent. Time-stability analysis indicated that 90 minutes of data collection generated stable outcome measures. Derivation of BP and k3/k4 by kinetic analys...Continue Reading

References

Aug 14, 1992·European Journal of Pharmacology·P H AndersenE B Nielsen
Sep 1, 1992·Journal of Computer Assisted Tomography·K WienhardW D Heiss
Jul 1, 1992·Journal of Computer Assisted Tomography·R P WoodsJ C Mazziotta
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A KoeppeD E Kuhl
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LoganS J Gatley
Jun 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J J FrostH N Wagner
Aug 31, 1988·Neuroscience Letters·J De KeyserG Vauquelin
Jan 1, 1986·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·C HalldinG Sedvall
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Dec 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·H HallL Farde
Aug 17, 1995·Nature·G V Williams, P S Goldman-Rakic
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y Y Huang, E R Kandel
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M LaruelleR B Innis
May 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M LaruelleP B Hoffer
May 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M LaruelleR B Innis
Jul 1, 1993·Journal of Computer Assisted Tomography·R P WoodsS R Cherry
Jan 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A A LammertsmaR S Frackowiak
Jul 1, 1995·The Journal of Antimicrobial Chemotherapy·M A Boogaerts
May 1, 1996·Journal of Computer Assisted Tomography·G J WangD J Schyler
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LoganD L Alexoff
Jul 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J H Meador-WoodruffS J Watson
Mar 5, 1997·European Journal of Pharmacology·A Abi-DarghamR B Innis
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·R BernabeuJ H Medina

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Citations

Oct 24, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dara M CannonWayne C Drevets
Nov 29, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jonathon A NyeMark M Goodman
Jan 30, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diana MartinezMarc Laruelle
Dec 24, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ragy R GirgisMark Slifstein
Feb 23, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nina Bl UrbanMarc Laruelle
Mar 15, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yun ZhouDean F Wong
May 3, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jesper EkelundMarc Laruelle
Feb 24, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nicolaas I Bohnen, Kirk A Frey
Jan 24, 2007·European Journal of Nuclear Medicine and Molecular Imaging·David ElmenhorstAndreas Bauer
Dec 24, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ana M CatafauMarc Laruelle
Jan 1, 2007·PET Clinics·Kimberly P Lindsey, S John Gatley
Aug 6, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Seongho SeoJae S Lee
Sep 4, 2007·Neuropsychologia·Alonso MontoyaMartin Lepage
Dec 7, 2006·Neuroimaging Clinics of North America·Kimberly P Lindsey, S John Gatley
Dec 20, 2003·Annals of the New York Academy of Sciences·Marc LaruelleAnissa Abi-Dargham
Feb 28, 2003·Seminars in Nuclear Medicine·Joanna S FowlerNora D Volkow
Jan 1, 2005·Drug Discovery Today. Technologies·Eugenii A Rabiner
May 22, 2016·Biological Psychiatry·Jodi J WeinsteinAnissa Abi-Dargham
Nov 26, 2009·NeuroImage·Yun ZhouDean F Wong
Sep 1, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R Maria MorescoF Fazio
Nov 18, 2005·International Review of Neurobiology·W Gordon FrankleMarc Laruelle
Feb 16, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Simon KallerOsama Sabri
Jul 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R V ParseyM Laruelle
Aug 29, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O MawlawiM Laruelle
Apr 11, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LoganD L Alexoff

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Methods Mentioned

BETA
saturation binding

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MEDx
MATLAB

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