Measurement of the 11C-flumazenil binding in the visual cortex predicts the prognosis of hemianopia

Journal of the Neurological Sciences
Yukihisa SuzukiKenji Ishii

Abstract

In order to determine whether functional neuroimaging studies can predict the prognosis of hemianopia due to organic cerebral disorders, we studied 8 patients (6 men and 2 women; age, 56.0+/-8.6 years) with homonymous hemianopia and compared them with 15 normal subjects (6 men and 9 women; age, 54.3+/-4.4 years). The cerebral glucose metabolism and 11C-flumazenil (FMZ) binding were measured by positron emission tomography, more than 1 month after the onset of the condition. Bilateral regions of interest (ROIs) were selected in the striate cortex, extrastriate cortex, cuneus and thalamus. Further, semi-quantitative data on the cerebral glucose metabolism and FMZ binding were obtained for the ROIs and compared with the data obtained for homologous regions in the contralateral hemisphere by calculating the ipsilateral/contralateral (I/C) ratio. The I/C ratios for the cerebral glucose metabolism and FMZ binding in the striate cortex were significantly low in the patients (glucose metabolism, P<0.0005; FMZ binding, P<0.005), while the ratio for the FMZ binding in the cuneus increased (P<0.0005). We observed that 5 patients, whose I/C ratio for the FMZ binding in the striate cortex was >0.850, experienced an improvement in their visu...Continue Reading

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Citations

Mar 3, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Charles M LaymonW Gordan Frankle
Jul 16, 2010·Geriatrics & Gerontology International·Kiichi IshiwataJun Toyohara
Apr 5, 2016·The Tohoku Journal of Experimental Medicine·Yukihisa SuzukiKenji Ishii

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