Measurement of the dynamic shear modulus of mouse brain tissue in vivo by magnetic resonance elastography.

Journal of Biomechanical Engineering
Stefan M AtayP V Bayly

Abstract

In this study, the magnetic resonance (MR) elastography technique was used to estimate the dynamic shear modulus of mouse brain tissue in vivo. The technique allows visualization and measurement of mechanical shear waves excited by lateral vibration of the skull. Quantitative measurements of displacement in three dimensions during vibration at 1200 Hz were obtained by applying oscillatory magnetic field gradients at the same frequency during a MR imaging sequence. Contrast in the resulting phase images of the mouse brain is proportional to displacement. To obtain estimates of shear modulus, measured displacement fields were fitted to the shear wave equation. Validation of the procedure was performed on gel characterized by independent rheometry tests and on data from finite element simulations. Brain tissue is, in reality, viscoelastic and nonlinear. The current estimates of dynamic shear modulus are strictly relevant only to small oscillations at a specific frequency, but these estimates may be obtained at high frequencies (and thus high deformation rates), noninvasively throughout the brain. These data complement measurements of nonlinear viscoelastic properties obtained by others at slower rates, either ex vivo or invasively.

References

Jan 1, 1990·Journal of Biomechanics·S S MarguliesT A Gennarelli
Apr 15, 2000·Journal of Magnetic Resonance Imaging : JMRI·D B PlewesC L Walker
Dec 4, 2001·Medical Image Analysis·A ManducaR L Ehman
Jan 5, 2002·Medical Engineering & Physics·K K Darvish, J R Crandall
Apr 6, 2002·Journal of Biomechanics·Karol Miller, Kiyoyuki Chinzei
May 11, 2002·Journal of Biomechanical Engineering·Michael T Prange, Susan S Margulies
Jul 28, 2004·Journal of Biomechanics·Amit Gefen, Susan S Margulies
Aug 18, 2004·Ultrasound in Medicine & Biology·S SrinivasanJ Ophir
Dec 4, 2004·IEEE Transactions on Medical Imaging·U TechavipooJ A Zagzebski
Jan 29, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R SinkusM Fink
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paul J McCrackenRichard L Ehman
Aug 9, 2005·Journal of Neurotrauma·P V BaylyG M Genin
Aug 10, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shadi F OthmanRichard L Magin
Sep 13, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A J RomanoR L Ehman
Oct 15, 2005·Ultrasound in Medicine & Biology·Hua XieJonathan M Rubin
Mar 22, 2006·Journal of Biomechanics·Philip V BaylyGuy M Genin
Feb 2, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·A J RomanoJ J Shirron

❮ Previous
Next ❯

Citations

Sep 14, 2010·Medical Physics·Phillip R PerriñezKeith D Paulsen
Jun 5, 2012·Annual Review of Biomedical Engineering·Philip V BaylyGuy M Genin
Dec 19, 2009·Physics in Medicine and Biology·B LarratM Tanter
Mar 24, 2011·Physics in Medicine and Biology·E H ClaytonP V Bayly
May 18, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Yuan FengPhilip V Bayly
Feb 14, 2012·Magnetic Resonance Imaging·Matthew C MurphyRichard L Ehman
Jul 12, 2011·Acta Biomaterialia·Thibault P PrevostSimona Socrate
Feb 8, 2011·Journal of Biomechanics·Kerstin RiekJürgen Braun
Sep 8, 2010·Magnetic Resonance Imaging·Matthew C MurphyRichard L Ehman
Jul 7, 2010·Acta Biomaterialia·Thibault P PrevostSimona Socrate
Mar 10, 2009·Journal of Biomechanics·Farhana Pervin, Weinong W Chen
Sep 19, 2012·Journal of Magnetic Resonance Imaging : JMRI·Kevin J GlaserRichard L Ehman
Oct 12, 2010·NMR in Biomedicine·Kaspar-Josche StreitbergerIngolf Sack
Mar 5, 2010·IEEE Transactions on Medical Imaging·Phillip R PerriñezKeith D Paulsen
Sep 30, 2010·IEEE Transactions on Medical Imaging·Emilie MacéMickael Tanter
Aug 27, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Badar RashidMichael D Gilchrist
Feb 24, 2015·Biomechanics and Modeling in Mechanobiology·Yi JiangYanping Cao
Jan 10, 2012·Journal of Biomechanics·B SanbornT Weerasooriya
Jul 27, 2010·Journal of Biomechanics·A J PattisonK D Paulsen
Aug 21, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Gwladys E LeclercSabine F Bensamoun
Nov 6, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gergely BertalanJürgen Braun
Oct 9, 2013·Journal of Neural Engineering·Arati SridharanJit Muthuswamy
Apr 16, 2020·Proceedings of the National Academy of Sciences of the United States of America·Christopher W BarneyAlfred J Crosby
Nov 22, 2019·Applied Spectroscopy Reviews·Jiang ZhuZhongping Chen
Mar 31, 2012·Physics in Medicine and Biology·Sebastian PapazoglouIngolf Sack
Dec 13, 2018·Frontiers in Neurology·Mathilde BigotSimon A Lambert
Oct 30, 2020·Frontiers in Neuroscience·Li-Ming HsuYen-Yu Ian Shih
Feb 23, 2021·Journal of Biomechanics·J D EscarcegaP V Bayly
Feb 6, 2018·Journal of Biomechanics·Charlotte A GuertlerPhilip V Bayly

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved