Measurement of the endolymphatic sac potential in human

Hearing Research
H KumagamiH Takahashi

Abstract

In this study, we measured human endolymphatic sac potential (ESP) in 8 patients with vestibular schwannoma and in five patients with Ménière's disease during surgery. ESP was measured with a glass electrode filled with 154 mM NaCl and with an outside tip diameter ranging from 2 to 3 microm. The mean value of human ESP in patients with vestibular schwannoma was +13.3+/-1.9 mV. Since electron microscopy showed that the endolymphatic sacs of the eight patients with vestibular schwannoma were normal in the ultrastructures the value can be close to normal human ESP. While in Ménière's disease, three cases showed low potentials and two cases showed almost the same values observed as in the eight patients with vestibular schwannoma. In the two cases with Ménière's disease, the epithelial cells of the endolymphatic sac were preserved. Our study can be considered as the first successful measurement of human ESP and revealed the existence of Ménière's disease having normal endolymphatic sac in function as well as morphology.

References

Jan 1, 1979·The Laryngoscope·R A SchindlerM Maglio
Jan 1, 1992·Acta Oto-laryngologica·H MasutaniI Sando
Jan 1, 1991·Acta Oto-laryngologica·N MoriS Sakai
Jan 1, 1990·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·N MoriS Sakai
Jun 1, 1969·Archives of Otolaryngology·G E ShambaughI K Arenberg
Apr 1, 1983·Archives of Oto-rhino-laryngology·H AmanoC Morgenstern
Sep 1, 1982·American Journal of Otolaryngology·A J Gulya, H F Schuknecht
Mar 1, 1997·The Annals of Otology, Rhinology, and Laryngology·N Danckwardt-LillieströmH Rask-Andersen
Apr 18, 1998·The Laryngoscope·V CouloignerE Ferrary

❮ Previous
Next ❯

Citations

Oct 2, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryuhei InamotoNozomu Mori

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.