PMID: 7542820Aug 1, 1995Paper

Measurement of the proportion of free to total prostate-specific antigen improves diagnostic performance of prostate-specific antigen in the diagnostic gray zone of total prostate-specific antigen

Urology
A A LudererM K Brawer

Abstract

This study examined the clinical significance of non-complexed (free) prostate-specific antigen (PSA) in the differential diagnosis of prostate cancer with an emphasis on patients with total PSA values between 4.0 and 10.0 ng/mL (the diagnostic gray zone). Serum samples were obtained from three specimen banks. Patient samples consisted of 55 untreated histologically confirmed primary cancer, 62 men with untreated benign prostatic disease histologically confirmed by 6 negative sextant biopsies, and 64 asymptomatic healthy male controls with normal digital rectal examinations and PSA values less than 4.0 ng/mL. All patients were between the ages of 50 and 75 years. Total PSA levels were determined using the PA immunoassay performed on the TOSOH AIA-1200 automated immunoassay instrument. Free PSA levels were determined using a monoclonal-polyclonal antibody sandwich radioimmunoassay. The proportion of free to total PSA was calculated by dividing the patient's free PSA value by the total PSA value. When all subjects were included, both total PSA and the proportion of free to total PSA significantly differentiated between patients with prostate cancer and patients with benign histologic conditions (P < 0.0001). However, in men with ...Continue Reading

Citations

Oct 1, 1996·Journal of Clinical Ultrasound : JCU·S W Melchior, M K Brawer
Jan 31, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·N E KushlinskiĭL M Gorilovskiĭ
Jul 1, 2000·Indian Journal of Clinical Biochemistry : IJCB·D Anitha, T Venkatesh
Jun 27, 2002·Current Urology Reports·M HanA W Partin
Apr 27, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·K MatsumotoT Samori

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