Measurement of tissue cortisol levels in patients with severe burns: a preliminary investigation.

Critical Care : the Official Journal of the Critical Care Forum
Jeremy CohenBala Venkatesh

Abstract

The assessment of adrenal function in critically ill patients is problematic, and there is evidence to suggest that measurement of tissue glucocorticoid activity may be more useful than estimation of plasma cortisol concentrations. Interstitial cortisol concentrations of cortisol represent the available pool of glucocorticoids able to enter the cell and bind to the glucocorticoid receptor. However the concentrations of plasma cortisol may not accurately reflect interstitial concentrations. We elected to perform a preliminary study into the feasibility of measuring interstitial cortisol by microdialysis, and to investigate the relationship between total plasma cortisol, free plasma cortisol and interstitial cortisol in patients with severe burns. A prospective observational study carried out in a tertiary intensive care unit. Ten adult patients with a mean total burn surface area of 48% were studied. Interstitial cortisol was measured by microdialysis from patient-matched burnt and non-burnt tissue and compared with that of 3 healthy volunteers. Plasma sampling for estimations of total and free cortisol concentrations was performed concurrently. In the burn patients, mean total plasma and free plasma cortisol concentrations were...Continue Reading

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Citations

Jul 2, 2010·Neurocritical Care·Juan Antonio Llompart-PouBartolomé Burguera
Feb 17, 2010·Critical Care : the Official Journal of the Critical Care Forum·Rizwan A Manji, Anand Kumar
Apr 17, 2014·PloS One·Radhika SusarlaSaaeha Rauz
Jul 16, 2010·Journal of Endocrinological Investigation·J A Llompart-PouJ M Raurich
Apr 4, 2013·Journal of Medical Engineering & Technology·R C BhakeS L Lightman
Oct 12, 2014·Advanced Drug Delivery Reviews·Xin LiuMichael S Roberts
Sep 20, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Bala Venkatesh, Jeremy Cohen
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Jan 5, 2011·Critical Care Medicine·Bala VenkateshJeremy Cohen
Sep 19, 2019·The Journal of Clinical Endocrinology and Metabolism·R BhakeS L Lightman
Jan 1, 2011·Expert Review of Endocrinology & Metabolism·Gulsah ElbukenFahrettin Kelestimur
Jan 1, 2014·Expert Review of Endocrinology & Metabolism·Federica D'AstaMaria Luisa Brandi
Feb 24, 2015·Critical Care Medicine·Miklos D Kertai, Manuel L Fontes
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Methods Mentioned

BETA
ELISA
enzyme linked immunosorbent assay

Software Mentioned

[UNK] Detection Platform
Multimode Analysis

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