Measurement of total RBC volume relative to lean body mass for diagnosis of polycythemia

American Journal of Clinical Pathology
N I Berlin, S M Lewis

Abstract

An elevated total RBC volume (TRCV) in milliliters per kilogram of body weight has been an essential criterion for determining whether a person is polycythemic. This may be misleading in obese subjects as the TRCV per kilogram of fat is only one-tenth that of the TRCV of the lean body mass (LBM). Various formulas based on surface area have been used to account for this difference, but they are not always reliable. Direct measurement of TRCV per kilogram of lean body mass was obtained originally in studies in which body composition was determined by the combined body density and total body water measurement method. This is impractical as a routine procedure, but simple-to-use instruments are now available for direct measurement of a person's body composition and percentage of fat by impedance technology. Thus, the TRCV can be obtained by a direct measurement that discounts the effects of fat, and a graph has been designed to normalize the TRCV to milliliters per kilogram of LBM. The TRCV for men and women has been established as 36 mL/kg LBM; when it is more than 43 mL/kg LBM, a diagnosis of polychthemia can be made with confidence.

References

Aug 1, 1989·The American Journal of Clinical Nutrition·R N BaumgartnerA F Roche
Oct 1, 1987·The American Journal of Clinical Nutrition·H C Lukaski
Apr 1, 1986·Journal of Applied Physiology·H C LukaskiW A Siders
Dec 1, 1984·The American Journal of Clinical Nutrition·J M ConwayC E Bodwell
Feb 1, 1996·American Journal of Epidemiology·D GallagherS B Heymsfield
Apr 25, 2000·Blood Cells, Molecules & Diseases·I BalgaM Furlan
Jan 1, 1956·The Journal of Clinical Investigation·R L HUFF, D D FELLER
Jan 1, 1956·Advances in Biological and Medical Physics·W E SIRI
Apr 1, 1960·The Journal of Clinical Investigation·E J WERDEIN, L H KYLE
Jul 1, 1962·British Journal of Haematology·R D HYDE, N F JONES
Apr 1, 1952·The Journal of Clinical Investigation·T C PRENTICEJ H LAWRENCE

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Citations

Feb 26, 2013·Physiological and Biochemical Zoology : PBZ·Regina EisertGraham K Barrell
Jul 13, 2002·Expert Review of Anticancer Therapy·Nathaniel I Berlin

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