Measurement of tumor volume by PET to evaluate prognosis in patients with head and neck cancer treated by chemo-radiation therapy

Acta Oncologica
Young Mi SeolEun Young Yun

Abstract

To evaluate the prognostic value of the metabolic tumor volume measured on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging and other clinical factors in patients treated for locally advanced head-and-neck cancer (HNC) at a single institution. Between June 2005 and August 2008, 59 patients with HNC that underwent pretreatment FDG-PET studies received neoadjuvant chemotherapy and radiation therapy. Metabolically active tumor regions were delineated on the pretreatment PET scans by a fixed SUV of 2.5. We evaluated the relationship of the 18F-fluorodeoxyglucose-PET maximum standardized uptake value (SUV) and the metabolic tumor volume (MTV) with the progression-free survival (PFS) and overall survival (OS). The MTV and lymph node metastasis were predictive of the PFS and OS. The lymph node status did not correlate with the MTV. A higher MTV of 9.3 cm(3) was significantly associated with an increased risk of recurrence (2.19-fold, p = 0.006) and death (1.62-fold, p = 0.051). Separation of patients with tumor volumes <or= 9.3 cm(3) and no lymph node disease vs. any other combination was strongly predictive of the PFS and the OS. MTV and lymph node status were prognostic values associated with survival. Quantitat...Continue Reading

References

Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J F VansteenkisteM G Demedts
Aug 31, 2001·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·R JacobR Amedee
May 23, 2002·International Journal of Radiation Oncology, Biology, Physics·Tom R Miller, Perry W Grigsby
Jul 28, 2004·International Journal of Radiation Oncology, Biology, Physics·Abdelkarim S AllalPavel Dulguerov
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J DowneyValerie Rusch
Dec 22, 2004·Archives of Otolaryngology--head & Neck Surgery·David L SchwartzKenneth Krohn
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ryohei SasakiJames D Cox
Jun 15, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gerben R BorstJoos V Lebesque
Nov 5, 2005·European Journal of Nuclear Medicine and Molecular Imaging·S M EschmannR Bares
Feb 24, 2006·American Journal of Surgery·Alicia N KieningerGary W Chmielewski
Feb 20, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J-L RohS Y Kim
May 4, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sang Yoon KimSung-Bae Kim
Sep 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Percy LeeBilly W Loo
Feb 2, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sang-wook LeeJong Hoon Kim
Feb 12, 2008·International Journal of Radiation Oncology, Biology, Physics·Matthew R VernonDian Wang
Jul 23, 2008·Archives of Otolaryngology--head & Neck Surgery·Shilpa S Chatni, Krishnakumar Thankappan

❮ Previous
Next ❯

Citations

Feb 26, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Maria HentschelKlaus Zöphel
Apr 5, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Dominic A X SchinaglJohannes H A M Kaanders
Sep 29, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Shengri LiaoYonglin Pu
Apr 26, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Chia-Hung KaoShang-Wen Chen
Aug 31, 2013·European Journal of Nuclear Medicine and Molecular Imaging·M PicchioI Castiglioni
Apr 6, 2012·European Radiology·Eric O AboagyeUNKNOWN Experimental Cancer Medicine Centre 13 Imaging Network Group
Sep 25, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G C ParkS Y Kim
Feb 26, 2013·AJR. American Journal of Roentgenology·Jessica DavisonRathan M Subramaniam
Nov 8, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Ronan AbgralPierre-Yves Salaün
Nov 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Christophe Van de WieleAlex Maes
Feb 25, 2014·Journal of Radiation Oncology·Adam A GarsaWade L Thorstad
Jan 14, 2011·Journal of Cancer Research and Clinical Oncology·Peng XieJinming Yu
Sep 6, 2013·Acta Oncologica·Bianca A W HoebenJohannes H A M Kaanders
Jun 18, 2015·The British Journal of Radiology·C JentschG Shakirin
Jun 28, 2012·Gynecologic Oncology·Elizabeth A KiddPerry W Grigsby
May 15, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Giovanni CammarotoUNKNOWN Young AIMN Working Group
Jan 25, 2012·International Journal of Radiation Oncology, Biology, Physics·Karen P ChuQuynh-Thu Le
Feb 5, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Dongyuan ZhuJinming Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
Trang H LaQuynh-Thu Le
Journal of Cancer Research and Clinical Oncology
Peng XieJin-Ming Yu
International Journal of Radiation Oncology, Biology, Physics
Percy LeeBilly W Loo
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Remy LimHeiko Schöder
© 2021 Meta ULC. All rights reserved