PMID: 11327372May 1, 2001Paper

Measurements of bone turnover markers in premature infants

Journal of Pediatric Endocrinology & Metabolism : JPEM
Y ShiffT Dolfin

Abstract

We determined the levels of circulating bone turnover markers in preterm infants during the first weeks of life. Twenty premature infants (mean gestational age 27+/-2.2 weeks, mean birth weight 894+/-231 g) hospitalized in the neonatal intensive care unit (NICU) at the Meir General Hospital, Israel, participated in the study. Measurements of bone turnover markers were performed at birth, and every week thereafter for an average follow-up of 11.2+/-0.7 weeks. Bone osteoblastic activity was assessed by measurements of circulating osteocalcin, bone-specific alkaline phosphatase (BSAP) and the C-terminal procollagen peptide (PICP) levels. Bone resorption was assessed by measurements of serum levels of the carboxy-terminal cross-links telopeptide of type I collagen (ICTP). All three markers of osteoblastic activity increased markedly and significantly during the first three weeks of life, and then continued to increase gradually until week 10 (p<0.01). Circulating ICTP levels increased in the first week of life and then decreased gradually throughout the follow-up (p<0.01). The study participants were divided into premature infants born at extremely low birth weight (ELBW: <1000 g, n=12) and very low birth weight (VLBW: 1000-1250 g,...Continue Reading

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Citations

Dec 14, 2006·Calcified Tissue International·I LitmanovitzA Eliakim
Nov 26, 2010·Journal of Paediatrics and Child Health·Yi-Li HungWu-Shiun Hsieh
Mar 25, 2017·Pediatric Exercise Science·Alon EliakimDan Nemet
Jul 18, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·C M VignochiL H Canani
Mar 7, 2003·Pediatric Research·Wolfgang HöglerKlaus Kapelari
Apr 23, 2003·Journal of Pediatric Endocrinology & Metabolism : JPEM·Alon EliakimTzipora Dolfin
Sep 22, 2006·Pediatric Research·Simone FunkeGyörgy Kosztolányi

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