Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion.

The American Journal of Physiology
C S Patlak, J D Fenstermacher

Abstract

Ventriculocisternal perfusions of mongrel dogs were performed for 1-6 h with solutions containing isotopically labeled compounds. At the conclusion of the perfusion period, serial brain samples were taken from the caudate nucleus and analyzed for radioactivity. Tissue concentration profiles were constructed from the data, and apparent tissue diffusion and capillary exchange coefficients were determined. The tissue diffusion constant of sucrose was 3 X 10(-6) cm2/s, which is approximately 45% of its free-water value. The permeability of the brain capillary complex to creatinine, sodium, and mannitol was so low that it could not be accurately measured by this technique. Capillary transfer coefficients, expressed as half-times, were determined for water, urea, and ethylene glycol; the t1/2 values were 1.5, 15, and 17 min, respectively. These numbers were converted to PS products and compared to other published values. This work suggests that the exchange of these compounds between blood and brain is partially (water) or nearly completely (urea and ethylene glycol) limited to membrane permeability.

Citations

Dec 1, 1977·British Journal of Pharmacology·H L Borison, L E McCarthy
Dec 1, 1988·Journal of Neurochemistry·G C NewmanC S Patlak
Jun 1, 1980·Journal of Pharmacokinetics and Biopharmaceutics·V A LevinH D Landahl
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LoganP King
Sep 4, 2003·Journal of Neuro-oncology·Edward RustamzadehWalter A Hall
May 23, 2006·American Journal of Physiology. Heart and Circulatory Physiology·J Stachowska-PietkaB Lindholm
Jan 1, 1988·Annals of the New York Academy of Sciences·J Fenstermacher, T Kaye
Dec 1, 1977·Circulation Research·E M Renkin
Mar 1, 1992·Journal of Neurochemistry·K H DykstraR L Dedrick
Dec 1, 1977·Circulation Research·E A RasioC A Goresky
Jan 1, 1983·Journal of Neuro-oncology·J M Collins
Apr 1, 1996·Pflügers Archiv : European journal of physiology·M HiroseT Yawata
Jun 11, 2009·Topics in Magnetic Resonance Imaging : TMRI·David Bonekamp, Katarzyna J Macura
Dec 31, 2005·Journal of Neurosurgery·John D HeissEdward H Oldfield
Feb 14, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert FrithiofRohit Ramchandra
Jul 5, 2017·Frontiers in Neurology·Carl-Henrik NordströmMagnus Olivecrona
Mar 1, 1984·Journal of Neurochemistry·Q R Smith, S I Rapoport
Dec 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S TakagiA J Gilson
Jun 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·N L SchlageterS I Rapoport
Feb 3, 2005·Journal of the National Cancer Institute·Janet C MillerJames H Thrall
Mar 13, 2017·Experimental Brain Research·Eric A HansenCornelius H Lam
Oct 21, 2018·Fluids and Barriers of the CNS·Stephen B Hladky, Margery A Barrand
May 31, 2020·Diagnostics·Jasleen KaurQuan Jiang
Dec 1, 1990·Clinical and Experimental Pharmacology & Physiology·P J Robinson
Jun 1, 1986·Journal of Neurochemistry·Q R Smith, S I Rapoport

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.