Measurements of ultrasonic backscattered spectral centroid shift from spine in vivo: methodology and preliminary results.

Ultrasound in Medicine & Biology
Brian S GarraKeith A Wear

Abstract

Ultrasonic backscatter measurements from vertebral bodies (L3 and L4) in nine women were performed using a clinical ultrasonic imaging system. Measurements were made through the abdomen. The location of a vertebra was identified from the bright specular reflection from the vertebral anterior surface. Backscattered signals were gated to isolate signal emanating from the cancellous interiors of vertebrae. The spectral centroid shift of the backscattered signal, which has previously been shown to correlate highly with bone mineral density (BMD) in human calcaneus in vitro, was measured. BMD was also measured in the nine subjects' vertebrae using a clinical bone densitometer. The correlation coefficient between centroid shift and BMD was r = -0.61. The slope of the linear fit was -160 kHz / (g/cm(2)). The negative slope was expected because the attenuation coefficient (and therefore magnitude of the centroid downshift) is known from previous studies to increase with BMD. The centroid shift may be a useful parameter for characterizing bone in vivo.

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Citations

Dec 3, 2014·Ultrasound in Medicine & Biology·Francesco ConversanoSergio Casciaro
Aug 21, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R BarkmannC C Glüer
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Mar 15, 2015·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Seo HeoHyungsuk Kim
Aug 27, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Chengcheng LiuWei-Qi Wang
Nov 2, 2015·The Journal of the Acoustical Society of America·Brent K HoffmeisterSang-Rok Lee
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Sep 5, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M Di PaolaM Rossini
May 16, 2020·Computational and Mathematical Methods in Medicine·Weiying MaoRong Zhang

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