PMID: 9647295Jul 1, 1998Paper

Measures of brain and spinal cord atrophy in multiple sclerosis

Journal of Neurology, Neurosurgery, and Psychiatry
N A Losseff, D H Miller

Abstract

Although conventional magnetic resonance imaging (MRI) has greatly increased the understanding of the pathophysiology of multiple sclerosis, its relation to the development of disability is complex. More pathologically specific imaging markers have therefore been sought to try and understand the underlying process that is responsible for the progressive disability that so commonly occurs in multiple sclerosis. Of these the most simple to understand conceptually is the measurement of atrophy, which most probably represents axonal loss. Several recent studies have shown that atrophy is a process closely linked with the progressive phase of multiple sclerosis and worsening disability. Furthermore it has also been shown that atrophy may evolve despite the absence of inflammatory activity as judged by gadolinium enhanced MRI and thus its measurement gives information in addition to that obtained from conventional MRI. Because of new developments in imaging we are now able to measure atrophy reliably and reproducibly. Hence the measurement of atrophy now provides objective markers by which to evaluate putative treatment aimed at preventing disability in multiple sclerosis.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Progress in Brain Research
Jeffrey K Huang, Robin J M Franklin
Neurología : publicación oficial de la Sociedad Española de Neurología
M AymerichX Montalbán
International Journal of Molecular Sciences
Rickie Patani, Siddharthan Chandran
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Tsuyoshi Ueta, Yuu Miyagawa
© 2022 Meta ULC. All rights reserved