Measures of left ventricular dyssynchrony and the correlation to clinical and echocardiographic response after cardiac resynchronization therapy

The American Journal of Cardiology
Raed AbdelhadiSamir Saba

Abstract

There is still no standardized measure of left ventricular (LV) dyssynchrony or definition of response in candidates of cardiac resynchronization therapy (CRT). Recipients of CRT underwent echocardiographic assessment of LV dyssynchrony before and immediately after implantation of a CRT device. Patients were followed for 6 months postimplantation. A total of 44 patients (64 +/- 12 years, 30 men, and 26 with ischemic cardiomyopathy) were included in this analysis. There was a significant decrease in both radial (304 +/- 137 vs 121 +/- 85 ms, p <0.001) and longitudinal (143 +/- 104 vs 95 +/- 43 ms, p = 0.02) measures of LV dyssynchrony immediately after CRT. The immediate post-CRT change in radial (r = -0.43, p = 0.015) but not longitudinal (r = -0.09, p = 0.61) LV dyssynchrony correlated with a significant improvement in the physical component of the quality-of-life score 6 months after CRT. Although a higher baseline longitudinal (p = 0.05) or radial (p = 0.025) LV dyssynchrony predicted a >or=1 improvement in New York Heart Association classification of heart failure 6 months after CRT, acute changes in neither radial (p = 0.71) nor longitudinal (p = 0.89) LV dyssynchrony were predictive of any improved echocardiographic outco...Continue Reading

References

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Citations

Jun 22, 2010·Journal of Cardiopulmonary Rehabilitation and Prevention·Karin F HothRonald A Cohen
Dec 5, 2009·The International Journal of Cardiovascular Imaging·Kenji KitaizumiMasakazu Kohno
Aug 15, 2014·Scandinavian Cardiovascular Journal : SCJ·Gani BajraktariMichael Y Henein
Aug 26, 2009·Pacing and Clinical Electrophysiology : PACE·Henneke VersteegSusanne S Pedersen
Oct 17, 2014·Pacing and Clinical Electrophysiology : PACE·Radosław LenarczykZbigniew Kalarus
Dec 18, 2008·European Journal of Clinical Investigation·F WiesbauerT Binder

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