Measuring and interpreting age-related loss of vertebral bone mineral density in a medieval population

American Journal of Physical Anthropology
Sabrina C Agarwal, M D Grynpas

Abstract

This study investigates the age- and sex-related patterns in vertebral bone mineral density (BMD) and the relationship between BMD and vertebral osteophytosis (VO), using a specialized peripheral densitometer in a skeletal sample excavated from the British medieval village Wharram Percy. A total of 58 individuals were divided by sex into three broad age categories (18-29, 30-49, 50+ years.). Each fourth intact vertebral centra was scored for VO and 5-mm thick coronal sections scanned in a specialized peripheral densitometer (GE Lunar Piximus DXA). Changes in BMD associated with age, sex, and VO severity were examined in the whole vertebral section, a strictly trabecular region, and a primarily cortical region of bone separately. Significant change in vertebral BMD was found to occur by middle age with little or no statistical change in BMD between middle and old age. Females appear to suffer greater bone loss at an earlier age with no change in BMD between middle and old age, whereas males show a more steady loss of BMD across the age groups. The bone mineral content and BMD of the cortical region is higher in individuals with pronounced/severe osteophytosis. The unusual age- and sex-related patterns of change in vertebral BMD ...Continue Reading

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Citations

Jan 26, 2016·American Journal of Physical Anthropology·Sabrina C Agarwal
May 24, 2011·American Journal of Human Biology : the Official Journal of the Human Biology Council·L Elizabeth DoyleSusan Pfeiffer
Dec 7, 2011·American Journal of Physical Anthropology·James H GosmanClark Spencer Larsen
Feb 8, 2018·American Journal of Human Biology : the Official Journal of the Human Biology Council·Amy C BeresheimAmanda Alblas
Sep 22, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christopher B RuffShannon C McFarlin
Mar 2, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Jacob S GriffinSteph M Berger
May 28, 2021·International Journal of Paleopathology·Anne-Marijn van SpeldeKerstin Lidén
Jul 18, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Sabrina C Agarwal

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