Measuring aqueous solubility in the presence of small cosolvent volume fractions by passive dosing

Environmental Science & Technology
Hyuck-Chul Kwon, Jung-Hwan Kwon

Abstract

A new passive dosing method was developed to determine aqueous solubility of hydrophobic chemicals. In the passive dosing method, chemical crystals were loaded to a polydimethylsiloxane (PDMS) phase to maintain the maximum chemical activity and to prevent direct contact of chemical crystals with the aqueous solution. Eight polycyclic aromatic hydrocarbons (PAHs) were chosen covering their literature aqueous solubility from 0.001 to 30 mg L(-1). Values of the aqueous solubility for less hydrophobic PAHs (naphthalene, 2-methylnaphthalene, and fluorene) were measured by an Organization for Economic Co-ordination and Development (OECD)-recommended generator column method and those for more hydrophobic PAHs (anthracene, chrysene, and benzo(a)pyrene) were measured by the passive dosing method. For phenanthrene and pyrene, both methods were used for comparison. The results obtained by the passive dosing method were very close to those obtained by the generator column method. Aqueous solubilities in deionized water for more hydrophobic PAHs obtained using the passive dosing method agreed very well with values reported in the literature, suggesting the utility of the passive dosing method for the determination of aqueous solubility for ...Continue Reading

References

Apr 17, 1999·International Journal of Pharmaceutics·A Jouyban-GharamalekiW E Acree
Sep 25, 2002·International Journal of Pharmaceutics·Jeffrey MillardS Yalkowsky
Mar 16, 2004·Water Research·Henry X CorseuilMarilda Fernandes
Apr 12, 2005·Environmental Science & Technology·E Ruckenstein, I Shulgin
Nov 18, 2005·Aquatic Toxicology·T H HutchinsonD B Pickford
Mar 28, 2009·Chemosphere·Jung-Hwan KwonBeate I Escher
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Beke T SeseBrian J Reid
May 27, 2010·Environmental Science & Technology·Katrin TannebergerKristin Schirmer
Oct 22, 2010·Chemical Research in Toxicology·Nynke I KramerJoop L M Hermens
Nov 1, 2011·Aquatic Toxicology·Marianne FrantzenLionel Camus
Nov 30, 2011·Environmental Health and Toxicology·Hyuck-Chul KwonJung-Hwan Kwon
Dec 1, 1995·Environmental Science & Technology·A Li, A W Andren
Jan 1, 1994·Environmental Science & Technology·A Li, A W Andren
Jun 1, 1984·Environmental Science & Technology·R W Walters, R G Luthy

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Citations

Jun 5, 2013·Ecotoxicology and Environmental Safety·So-Young LeeJung-Hwan Kwon
Feb 5, 2014·Environmental Science & Technology·Hyun-Joong KangJung-Hwan Kwon
Apr 3, 2016·Journal of Hazardous Materials·Hyun-Joong KangJung-Hwan Kwon
Sep 10, 2020·International Journal of Environmental Research and Public Health·So-Young Lee, Jung-Hwan Kwon
Sep 29, 2019·Analytica Chimica Acta·Heidi BirchPhilipp Mayer

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