Measuring change in quality of life in response to Helicobacter pylori eradication in peptic ulcer disease: the QOLRAD

Digestive Diseases and Sciences
J CrawleyI Wiklund

Abstract

This study was designed to determine if a new condition-specific quality of life measure, the Quality Of Life in Reflux And Dyspepsia (QOLRAD), was responsive to clinical change over a four-week period when evaluating peptic ulcer disease patients undergoing Helicobacter pylori (Hp) eradication. A secondary aim was to evaluate QOLRAD's psychometric performance. Hp-positive patients with peptic ulcer disease were recruited from primary care and gastroenterology clinics (N = 155). QOLRAD scores improved significantly (P < 0.0001) and mean total score increase was 1.07 points on a 7-point scale among 111 subjects who responded to Hp eradication. Effect sizes were moderate for responders (0.64) and low for nonresponders (0.36). Score changes below 0.60 were associated with the smallest improvement in patient and physician condition rating; scores above 1.2 were associated with the greatest improvement. The QOLRAD demonstrates reliability and validity. Changes in QOLRAD score can be meaningfully related to clinical changes, aiding evaluation of health-related quality of life in peptic ulcer disease.

Citations

Mar 28, 2008·Alimentary Pharmacology & Therapeutics·O ChassanyK Devault
Mar 14, 2009·European Journal of Gastroenterology & Hepatology·Julio PonceUNKNOWN Members of the IBERGE study group
Jan 31, 2006·Alimentary Pharmacology & Therapeutics·M A PuhanH J Schünemann
Aug 30, 2006·Scandinavian Journal of Gastroenterology·Jorgen UrnesHermod Petersen
Mar 27, 2007·Best Practice & Research. Clinical Gastroenterology·Paul Moayyedi
Apr 7, 2010·The American Journal of Medicine·Alan Barkun, Grigorios Leontiadis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.