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Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

bioRxiv

Mar 17, 2014

Traver HartJason Moffat

Abstract

Technological advancement has opened the door to systematic genetics in mammalian cells. Genome-scale loss-of-function screens can assay fitness defects induced by partial gene knockdown, using RNA interference, or complete gene knockout, using new CRISPR techniques. These screens can r...read more

Mentioned in this Paper

Hyperplasia
Assay
Knock-out
Screening Generic
Neoplasms
Genomic Screening
Gene Knockdown Techniques
RNA
Clustered Regularly Interspaced Short Palindromic Repeats
CRISPR-Cas Systems
3
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Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

bioRxiv

Mar 17, 2014

Traver HartJason Moffat

PMID: 990003327

DOI: 10.1101/003327

Abstract

Technological advancement has opened the door to systematic genetics in mammalian cells. Genome-scale loss-of-function screens can assay fitness defects induced by partial gene knockdown, using RNA interference, or complete gene knockout, using new CRISPR techniques. These screens can r...read more

Mentioned in this Paper

Hyperplasia
Assay
Knock-out
Screening Generic
Neoplasms
Genomic Screening
Gene Knockdown Techniques
RNA
Clustered Regularly Interspaced Short Palindromic Repeats
CRISPR-Cas Systems
3

Similar Papers Found In These Feeds

Paper Details
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