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Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

bioRxiv

Mar 17, 2014

Traver HartJason Moffat

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Abstract

Technological advancement has opened the door to systematic genetics in mammalian cells. Genome-scale loss-of-function screens can assay fitness defects induced by partial gene knockdown, using RNA interference, or complete gene knockout, using new CRISPR techniques. These screens can r...read more

Mentioned in this Paper

CRISPR-Cas Systems
Gene Knockout Techniques
Genomic Screening
Functional Genomics
Knock-out
Gene Knockdown Techniques
Genome
RNA
Classification
Cell Proliferation
3
Paper Details
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  • Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

    bioRxiv

    Mar 17, 2014

    Traver HartJason Moffat

    PMID: 990003327

    DOI: 10.1101/003327

    Abstract

    Technological advancement has opened the door to systematic genetics in mammalian cells. Genome-scale loss-of-function screens can assay fitness defects induced by partial gene knockdown, using RNA interference, or complete gene knockout, using new CRISPR techniques. These screens can r...read more

    Mentioned in this Paper

    CRISPR-Cas Systems
    Gene Knockout Techniques
    Genomic Screening
    Functional Genomics
    Knock-out
    3
    Paper Details
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