Measuring gastric emptying: comparison of 13C-octanoic acid breath test and scintigraphy

Digestive Diseases and Sciences
Jari PunkkinenJari Koskenpato

Abstract

The aim of this study was to compare scintigraphy, the standard method, and the (13)C-octanoic acid breath test (OBT) for measuring gastric emptying. Patients with functional dyspepsia (N = 21, 8 men and 13 women; ages, 40-75) underwent standardized dynamic scintigraphy and OBT. Scintigraphic images were obtained for 90 min and breath samples for 4 hr. The gastric half-emptying time for solids (T(1/2)) was calculated by two previously described mathematical models for the OBT samples: the nonlinear least-squares method and the geometrical method. T(1/2) was significantly longer measured by OBT than by scintigraphy (167 +/- 50 min for the nonlinear least-squares method (P < 0.05) and 185+/- 52 min for the geometrical method (P < 0.005) vs. 109 +/- 74 min for scintigraphy). No correlation appeared between T(1/2) measured by scintigraphy and T(1/2) measured by OBT (r = 0.26) for nonlinear least-squares method and (r = -0.13) for geometrical method). Furthermore, the correlation between the two mathematical models appeared to be low (r = 0.15). Although OBT is simple and safe, its correlation with scintigraphy appears to be weak. The usefulness of this test for measuring gastric emptying thus requires further validation.

References

Nov 1, 1982·The American Journal of Clinical Nutrition·A C Bach, V K Babayan
Feb 3, 1998·The American Journal of Gastroenterology·M G ChoiK S Nair
Jul 4, 1998·Digestive Diseases and Sciences·J KoskenpatoM Färkkilä
Feb 3, 2000·European Journal of Gastroenterology & Hepatology·B DelbendeJ P Galmiche
Apr 25, 2001·Journal of Clinical Gastroenterology·W D CheyK Goodman
May 20, 2004·Rapid Communications in Mass Spectrometry : RCM·Sarah J JacksonW Andrew Coward

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Citations

Dec 25, 2007·Critical Care : the Official Journal of the Critical Care Forum·Nam Q NguyenMichael Horowitz
Jun 13, 2012·World Journal of Gastroenterology : WJG·Chourouk EttreikiPauline M Anton
May 5, 2016·Journal of Food Engineering·T E MoxonS Bakalis
Jan 25, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P JanssenJ Tack
Jul 16, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kirsteen GoodmanClive G Wilson
Jun 3, 2014·Expert Review of Gastroenterology & Hepatology·William L Hasler
Sep 1, 2007·Journal of Breath Research·Anil S Modak
May 4, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N DelzenneM Westerterp-Plantenga
May 7, 2010·Scandinavian Journal of Gastroenterology·Miriam E Clegg, Amir Shafat

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