Measuring glomerular filtration rate with cystatin C and beta-trace protein in children with spina bifida

The Journal of Urology
Anne Pham-HuyGuido Filler

Abstract

We compared the diagnostic performance of cystatin C and beta-trace protein with serum creatinine and the Schwartz formula for the estimation of glomerular filtration rate in children with spina bifida. Cystatin C, beta-trace protein and serum creatinine in children who underwent routine measurement of glomerular filtration rate were obtained in a prospective study. A spina bifida group (27 measurements in 27 patients 1.4 to 20.0 years old, 15 female, 12 male) was compared with a group of controls (211 measurements in 201 patients with various other renal pathologies 1.0 to 20.2 years old, 89 female, 122 male). All patients underwent nuclear medicine clearance investigations with 99mtechnetium diethylenetetraminepentaacetic acid. Z scores were calculated for body mass index, height and weight. Receiver operating characteristic (ROC) analysis and ROC plots were done to assess their diagnostic accuracy. Serum creatinine and the Schwartz formula did not correlate with glomerular filtration rate in the patients with spina bifida. Correlation coefficients for cystatin C were 0.45 and 0.84 in the spina bifida and control groups, respectively, while correlation coefficients for beta-trace protein were 0.31 and 0.75, respectively. For ...Continue Reading

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Citations

Feb 19, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido FillerMara Medeiros
Jul 14, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Arend BökenkampRegina Bökenkamp
Oct 9, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Catherine MorganManjula Gowrishankar
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Dec 2, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Amina BenlamriGuido Filler
Sep 5, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Trine Borup AndersenJens Brøchner-Mortensen
Feb 26, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido Filler, Nathalie Lepage
Jan 14, 2011·International Urology and Nephrology·Guido FillerSumit Dave
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Sep 10, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Florian BrinkertRainer Ganschow
Jun 27, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Guido FillerErika Bariciak
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