Measuring gustatory variation in mice: a short-term fluid-intake test

Physiology & Behavior
B Kotlus, David A Blizard

Abstract

A short-term fluid-intake test is described which is directed at the study of individual variation in gustation in laboratory mice. To avoid position preferences associated with two-bottle tests, single graduated cylinders are used to present the solution. Intake of water and solutions is recorded for a 6-h period beginning 3 h prior to the dark phase of the light cycle. The timing of data collection ensures a stable baseline of fluid intake because it coincides with the period in which mice begin to drink. Food and water are available ad lib. at all other times so the test avoids the water restriction that is often used in gustatory studies. We report normative data on ten commonly used inbred strains for sucrose (100 mM), saccharin (10 mM), quinine (1.1 mM), HCI (1 and 3 mM). NaCl (320 mM), and monosodium glutamate (150 mM). Strain differences were pronounced for all tastants. Concurrent measures of food and fluid intake by C57BL/6J and DBA/2J mice demonstrated that the short-term reduction of fluid intake resulting from 6-h quinine administration, which was restricted to C57BL/6J mice, was associated with a minor reduction in food intake during the 6-h test and had no statistically significant effect on food or fluid intake ...Continue Reading

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Citations

Nov 11, 2006·Behavior Genetics·David A Blizard
Sep 7, 1999·Physiology & Behavior·M E Frank, D A Blizard
Oct 30, 2001·Behavioural Brain Research·H WelzlH P Lipp
Feb 6, 2002·Brain Research Bulletin·Tamio FuruseTsuyoshi Koide
Sep 9, 2008·Chemical Senses·A Rebecca GlattJohn D Boughter
Feb 4, 2009·Chemical Senses·Yutaka Ishiwatari, Alexander A Bachmanov
Feb 2, 2012·Chemical Senses·Yutaka Ishiwatari, Alexander A Bachmanov
Nov 9, 2010·Addiction Biology·Brian A McCool, Ann M Chappell
Jan 20, 2007·Genes, Brain, and Behavior·J S RhodesJ C Crabbe
Oct 18, 2007·BMC Neuroscience·John D Boughter, Alexander A Bachmanov
Jul 22, 2008·Physiology & Behavior·Michael G TordoffMaureen P Lawler
Sep 4, 2007·Physiology & Behavior·Alexander A Bachmanov, Gary K Beauchamp
Aug 25, 2004·Behavioural Brain Research·Stéphanie PothionCatherine Belzung
May 26, 2004·Pharmacology, Biochemistry, and Behavior·Laura Cousino KleinHelen M Kamens
May 2, 2006·Physiology & Behavior·Anthony Sclafani
Jan 18, 2019·Genes, Brain, and Behavior·Thomas ContesseOlivier Deschaux
Jul 12, 2011·Flavour and Fragrance Journal·Alexander A BachmanovGary K Beauchamp
Mar 16, 2019·Journal of Animal Science·Jaime FigueroaDominic M Dwyer

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