Measuring outcomes as a function of baseline severity of ischemic stroke

Cerebrovascular Diseases
H P AdamsW Hacke

Abstract

The spectrum of neurological impairments following acute ischemic stroke is broad. The initial stroke severity predicts responses to treatment and outcomes after ischemic stroke. While clinical trials are using baseline severity as an enrollment criterion or a stratified variable, adjustment of outcome measures as a function of initial impairments has not been done. We developed a responder analysis that defines favorable outcomes at 90 days as influenced by the baseline National Institutes of Health Stroke Scale (NIHSS). Favorable outcome was defined as a modified Rankin Scale (mRS) score of 0 if the baseline NIHSS score was <8, mRS score of 0-1 if the NIHSS score was 8-14, and mRS score of 0-2 if the NIHSS score was >14. The concept stemmed from the data of two European rtPA trials. The analysis is a predefined secondary endpoint in a trial testing abciximab. We also used the analysis to reexamine the Trial of Org 10172 in Acute Stroke Treatment data. The responder analysis did not change the overall results of any of the 3 previous trials, but it did give information about differences in responses among subgroups of patients. Evidence about the potential utility of tPA for treatment of patients with mild stroke appeared from...Continue Reading

References

Jun 1, 1989·Stroke; a Journal of Cerebral Circulation·J M BamfordJ Slattery
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottV Hertzberg
May 17, 2003·Stroke; a Journal of Cerebral Circulation·Marc Fisher, UNKNOWN Stroke Therapy Academic Industry Roundtable

❮ Previous
Next ❯

Citations

Jul 9, 2008·Current Atherosclerosis Reports·Pitchaiah MandavaThomas A Kent
May 17, 2005·Journal of Neurotrauma·Gordon D MurrayChristopher J Weir
Jun 15, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·C-Y HsuN J Douglas
Jun 9, 2005·Cerebrovascular Diseases·Hanne ChristensenThomas Truelsen
Oct 17, 2009·Stroke; a Journal of Cerebral Circulation·Karen C JohnstonUNKNOWN GRASP Investigators
Jul 28, 2011·Neurocritical Care·C E HallUNKNOWN First Neurocritical Care Research Conference Investigators
Jun 16, 2012·AJNR. American Journal of Neuroradiology·A MurphyR I Aviv
Sep 18, 2010·Stroke Research and Treatment·Yonghua Zhang, Michael A Meyer
Jun 5, 2013·Stroke; a Journal of Cerebral Circulation·Sharon D Yeatts
Jun 4, 2014·Disability and Rehabilitation·Tal AdamitNoomi Katz
Oct 5, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Dilaver KayaM Necmettin Pamir
Mar 20, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Askiel BrunoUNKNOWN SHINE investigators
Jun 16, 2006·Acta Neurologica Scandinavica·L ErnonV Thijs
Sep 22, 2012·Annals of the New York Academy of Sciences·Andrew M Southerland, Karen C Johnston
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Dorothy F EdwardsAlexander W Dromerick
Apr 16, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Simona LattanziMauro Silvestrini
Apr 23, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Simona LattanziMauro Silvestrini
Mar 4, 2014·Journal of the Neurological Sciences·Laura BurattiMauro Silvestrini
Jun 15, 2010·Topics in Stroke Rehabilitation·Louise Gustafsson, Kryss McKenna
Oct 7, 2009·Cerebral Cortex·Vincenzo Di LazzaroM Dileone
Jun 19, 2013·Neurorehabilitation and Neural Repair·Jill SeeSteven C Cramer
Jan 26, 2018·American Journal of Physical Medicine & Rehabilitation·Marco FranceschiniUNKNOWN Italian Study Group on Implementation of Stroke Care (ISC Study)
Sep 24, 2005·Stroke; a Journal of Cerebral Circulation·Carlos A Molina, Jeffrey L Saver
Sep 6, 2008·Stroke; a Journal of Cerebral Circulation·Harold P AdamsUNKNOWN AbESTT-II Investigators
Jan 20, 2007·Stroke; a Journal of Cerebral Circulation·Jeffrey L Saver, Banafsheh Yafeh
Feb 26, 2005·Stroke; a Journal of Cerebral Circulation·UNKNOWN Abciximab Emergent Stroke Treatment Trial (AbESTT) Investigators
Jan 28, 2006·Stroke; a Journal of Cerebral Circulation·Askiel BrunoLinda S Williams
Mar 17, 2009·Stroke; a Journal of Cerebral Circulation·Pitchaiah Mandava, Thomas A Kent
Apr 28, 2007·Stroke; a Journal of Cerebral Circulation·UNKNOWN Optimising Analysis of Stroke Trials (OAST) CollaborationJames Carpenter
May 10, 2005·Stroke; a Journal of Cerebral Circulation·Michael KramsDonald A Berry
Mar 20, 2012·Stroke; a Journal of Cerebral Circulation·Philip M W BathUNKNOWN European Stroke Organisation Outcomes Working Group
Aug 6, 2005·Stroke; a Journal of Cerebral Circulation·Maarten UyttenboogaartGert-Jan Luijckx
Jul 25, 2019·JAMA : the Journal of the American Medical Association·Karen C JohnstonUNKNOWN Neurological Emergencies Treatment Trials Network and the SHINE Trial Investigators
Aug 18, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Maria Kamieniarz-MędrygałRadosław Kaźmierski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.