Measuring particle size distribution of nanoparticle enabled medicinal products, the joint view of EUNCL and NCI-NCL. A step by step approach combining orthogonal measurements with increasing complexity

Journal of Controlled Release : Official Journal of the Controlled Release Society
Fanny CaputoA Prina-Mello

Abstract

The particle size distribution (PSD) and the stability of nanoparticles enabled medicinal products (NEP) in complex biological environments are key attributes to assess their quality, safety and efficacy. Despite its low resolution, dynamic light scattering (DLS) is the most common sizing technique since the onset of NEP in pharmaceutical technologies. Considering the limitations of the existing sizing measurements and the challenges posed by complex NEPs both scientists and regulators encourage the combination of multiple orthogonal high-resolution approaches to shed light in the NEP sizing space (e.g. dynamic light scattering, electron microscopy, field flow fractionation coupled to online sizing detectors, centrifugal techniques, particle tracking analysis and tunable resistive pulse sensing). The pharmaceutical and biotechnology developers are now challenged to find their own pragmatic characterisation approaches, which should be fit for purpose and minimize costs at the same time, in a complicated landscape where only a few standards exist. In order to support the community, the European Nanomedicine Characterisation Laboratory (EUNCL) and the US National Cancer Institute Nanotechnology Characterization Laboratory (NCI-NCL...Continue Reading

Citations

Dec 13, 2019·Pharmaceutical Research·Jeffrey D ClogstonPatrick Lim Soo
Feb 11, 2020·Drug Delivery and Translational Research·Tamara G DacobaJosé Crecente-Campo
Jul 5, 2019·Nature Nanotechnology·Hon S LeongChiara Pastore
Aug 25, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Rachael M CristStephan T Stern
Nov 30, 2019·Analytical and Bioanalytical Chemistry·Yingwen HuJeffrey D Clogston
Aug 8, 2020·Environmental Science and Pollution Research International·Nimmy Kumar, Jobin Jose
Dec 5, 2020·Journal of Pharmaceutical Sciences·Christian GruneDagmar Fischer
Jan 31, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Vinu VijayanManikantan Syamala Kiran
Feb 28, 2021·Colloids and Surfaces. B, Biointerfaces·Agnese GagliardiDonato Cosco
Feb 23, 2021·Frontiers in Pharmacology·Agnese GagliardiDonato Cosco
Jan 29, 2021·ChemMedChem·Marta GozziEvamarie Hey-Hawkins
Oct 5, 2020·Journal of Pharmaceutical and Biomedical Analysis·Yuchen FanKelly Zhang
Apr 24, 2021·Drug Discovery Today·Vincent LebretonFrederic Lagarce
Mar 23, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R MildnerF Caputo
Jul 3, 2021·Plants·Heba M M Abdel-AzizGhada A El-Sherbeny
Jun 16, 2021·Carbohydrate Polymers·Salma A FereigMona M A Abdel-Mottaleb
Jul 1, 2021·Nanoscale·Nicolas RolleyBrice Calvignac
Jul 25, 2021·Drug Delivery and Translational Research·Snežana ĐorđevićMaría J Vicent
Jul 20, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Florence FranconiPatrick Saulnier
Mar 27, 2021·Annual Review of Analytical Chemistry·Christine L PlavchakS Kim Ratanathanawongs Williams
Nov 14, 2020·Biomacromolecules·Kazuki SumiyaKazuo Sakurai
Aug 28, 2021·International Journal of Molecular Sciences·Gudrun C ThurnerPaul Debbage
Jun 26, 2020·The Journal of Physical Chemistry. B·Rintaro TakahashiKazuo Sakurai
Aug 29, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sheyda ShakibaStacey M Louie
Nov 23, 2021·Analytical Chemistry·Olenka Jibaja Valderrama, Ivo Nischang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Scientific American
Rodger Doyle
Medical Products Sales : MPS : the Official Journal of the American Surgical Trade Association
M D Thill, L Humphrey
© 2022 Meta ULC. All rights reserved