Measuring peripheral oxytocin and vasopressin in nonhuman primates

American Journal of Primatology
Toni E Ziegler

Abstract

Studying the neural and hormonal changes that modulate behavior is critical to understanding social relationships. Of particular interest is measuring oxytocin (OT) and arginine vasopressin (AVP) peripherally, and preferably, non-invasively, in nonhuman primates. Due to these peptides' neural origin and their stimulation of brain areas that influence social behavior, there has been debate whether peripheral measures in blood, urine, and saliva reflect central levels in the brain. This review elucidates the challenges of OT measurement and the solutions that provide valuable data on OT's role in social behavior. This review discusses the recent studies in rhesus macaques which indicate that exogenous OT delivered by nasal spray results in increased OT in cerebrospinal fluid, and it notes the new methodologies that can measure both endogenous and exogenous OT simultaneously, which thereby determine the source of measured OT in biological fluids. Next, this review highlights the utility of measuring urinary OT by summarizing the results of clearance rate studies in humans and marmosets, which characterize the timing that circulating OT enters urine and illustrate that endogenous releasers of OT also increase urinary OT. With the a...Continue Reading

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Citations

Jul 31, 2019·American Journal of Primatology·Melissa R BergKristine Coleman
Oct 4, 2018·American Journal of Primatology·Sara M Freeman, Karen L Bales
Oct 17, 2020·The International Journal of Neuroscience·Emine PetekkayaAbdullah Arpacı
Aug 13, 2021·Frontiers in Veterinary Science·Takumi NagasawaHidehiko Uchiyama

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