Measuring retinal blood flow in rats using Doppler optical coherence tomography without knowing eyeball axial length

Medical Physics
Wenzhong LiuHao F Zhang

Abstract

Doppler optical coherence tomography (OCT) is widely used for measuring retinal blood flow. Existing Doppler OCT methods require the eyeball axial length, in which empirical values are usually used. However, variations in the axial length can create a bias unaccounted for in the retinal blood flow measurement. The authors plan to develop a Doppler OCT method that can measure the total retinal blood flow rate without requiring the eyeball axial length. The authors measured the retinal blood flow rate using a dual-ring scanning protocol. The small and large scanning rings entered the eye at different incident angles (small ring: 4°; large ring: 6°), focused on different locations on the retina, and detected the projected velocities/phase shifts along the probing beams. The authors calculated the ratio of the projected velocities between the two rings, and then used this ratio to estimate absolute flow velocity. The authors tested this method in both Intralipid phantoms and in vivo rats. In the Intralipid flow phantom experiments, the preset and measured flow rates were consistent with the coefficient of determination as 0.97. Linear fitting between preset and measured flow rates determined the fitting slope as 1.07 and the interc...Continue Reading

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Citations

Oct 21, 2016·Photoacoustics·Wenzhong Liu, Hao F Zhang
Oct 19, 2017·Journal of Biomedical Optics·Xiao ShuHao F Zhang
May 19, 2021·Translational Vision Science & Technology·Michelle R TamplinIsabella M Grumbach

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