Measuring the effects of exercise in neuromuscular disorders: a systematic review and meta-analyses

Wellcome Open Research
Renae J StefanettiGráinne S Gorman

Abstract

Background: The benefit and safety of exercise training for patients with neuromuscular disorders (NMDs) has long been a contentious topic. This is, in part, due to recognised challenges associated with rare diseases including small and heterogenous patient populations. We performed a systematic review and meta-analyses to evaluate the effectiveness and safety of interventional exercise and establish minimal clinically important differences (MCID) in outcomes to facilitate clinical interpretation. Methods: We searched six databases from inception to Mar 2018. Aerobic, strength, and combined (aerobic and strength) intervention were eligible. Meta-analyses compared outcomes at baseline with those after at least six weeks (before-after exercise within individuals). A further meta-analysis compared outcomes before-after exercise between groups (exercise training versus usual care). Disease heterogeneity was explored using a random effect model. This study was registered (PROSPERO, CRD42018102183). An interactive database was developed to facilitate full interrogations of data. Results: We identified 130 articles describing 1,805 participants with 35 different forms of NMD. Of these studies, 76 were suitable for meta-analyses. Withi...Continue Reading

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Citations

Mar 2, 2021·Molecular Diagnosis & Therapy·Rory J TinkerRobert McFarland
Jul 17, 2020·Wellcome Open Research·Renae J StefanettiGráinne S Gorman
May 25, 2021·The Cochrane Database of Systematic Reviews·Katherine JonesGita Ramdharry
Jun 20, 2021·Lancet Neurology·Yi Shiau NgDoug M Turnbull
Nov 2, 2021·Frontiers in Physiology·Eduardo Salazar-MartínezAlejandro Lucia
Jun 24, 2021·Deutsches Ärzteblatt International·Thomas KlopstockHolger Prokisch
Oct 14, 2021·Endocrine Reviews·Yi Shiau NgMark Walker

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Methods Mentioned

BETA
biopsy

Software Mentioned

metafor
Cochrane
NIH
R
PRISMA

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