Measuring the patient response to dialysis therapy: hemodiafiltration and clinical trials

Kidney International
Mark R Marshall

Abstract

There is a strong biological plausibility for benefit from removal of larger uremic toxins and increasing positive clinical experience with hemodiafiltration. However, evidence supporting hemodiafiltration is not definitive with studies that are often limited by serious methodological shortcomings. Morena et al. show that hemodiafiltration may prevent intradialytic hypotension, albeit in a study that also has some shortcomings. Ongoing research for hemodiafiltration is still needed through high-quality clinical trials that adhere to standards for clinical trial conduct and reporting.

References

Feb 9, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco PizzarelliGiuseppe Ferro
Jul 26, 2008·Annals of Epidemiology·Onyebuchi A ArahSander Greenland
Jan 25, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·James E TattersallUNKNOWN EUDIAL group
Feb 16, 2013·Journal of the American Society of Nephrology : JASN·Francisco MaduellUNKNOWN ESHOL Study Group
Oct 2, 2014·Journal of the American Society of Nephrology : JASN·Jennifer E FlytheSteven M Brunelli

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Citations

Mar 9, 2019·Journal of the American Society of Nephrology : JASN·Rukshana ShroffFranz Schaefer
Aug 14, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard A WardBengt Lindholm

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