Measuring the Size of the Latent Human Immunodeficiency Virus Reservoir: The Present and Future of Evaluating Eradication Strategies.

The Journal of Infectious Diseases
Timothy J HenrichSatish K Pillai

Abstract

One of the major barriers to the successful design and implementation of human immunodeficiency virus (HIV) curative strategies is the limited ability to sensitively, specifically, and precisely quantify and characterize the whole-body burden of replication-competent HIV in individuals on effective antiretroviral therapy. Here, we review the development and validation of assays that directly and indirectly measure the size and distribution of the reservoir in blood and tissues. We also discuss the role that treatment interruptions will have in validating these assays and ultimately as a "proof of cure."

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Citations

Dec 20, 2017·Journal of Neurovirology·Benjamin B GelmanDennis Kolson
Dec 19, 2017·Frontiers in Immunology·Vasco RodriguesPhilippe Benaroch
Jun 30, 2018·Current Opinion in HIV and AIDS·Kathryn E Stephenson
Jul 19, 2018·Current Opinion in HIV and AIDS·Christine RouziouxVéronique Avettand-Fenoël
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Apr 13, 2019·PLoS Computational Biology·Daniel I S RosenbloomUNKNOWN Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group
Jul 28, 2019·The Journal of Experimental Medicine·Christian GaeblerMichel C Nussenzweig
Jul 12, 2017·AIDS Research and Human Retroviruses·Rebecca RoseMichael S McGrath
May 22, 2020·Drugs·Lucia Bailon AlvarezChristian Brander
Jul 30, 2020·International Journal of Molecular Sciences·Saifudeen IsmaelTauheed Ishrat
Jan 11, 2020·Frontiers in Microbiology·Shane D FalcinelliNancie M Archin
Mar 21, 2018·Frontiers in Immunology·Kimberly Schmitt, Ramesh Akkina
May 3, 2019·Nature Communications·Luc BertrandMichal Toborek

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