Meat and meat mutagens and risk of prostate cancer in the Agricultural Health Study

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Stella KoutrosRashmi Sinha

Abstract

Meats cooked at high temperatures, such as pan-frying or grilling, are a source of carcinogenic heterocyclic amines and polycyclic aromatic hydrocarbons. We prospectively examined the association between meat types, meat cooking methods, meat doneness, and meat mutagens and the risk for prostate cancer in the Agricultural Health Study. We estimated relative risks and 95% confidence intervals (95% CI) for prostate cancer using Cox proportional hazards regression using age as the underlying time metric and adjusting for state of residence, race, smoking status, and family history of prostate cancer. During 197,017 person-years of follow-up, we observed 668 incident prostate cancer cases (613 of these were diagnosed after the first year of follow-up and 140 were advanced cases) among 23,080 men with complete dietary data. We found no association between meat type or specific cooking method and prostate cancer risk. However, intake of well or very well done total meat was associated with a 1.26-fold increased risk of incident prostate cancer (95% CI, 1.02-1.54) and a 1.97-fold increased risk of advanced disease (95% CI, 1.26-3.08) when the highest tertile was compared with the lowest. Risks for the two heterocyclic amines 2-amino-3...Continue Reading

References

Apr 1, 1979·Journal of the National Cancer Institute·L A Poirier, E K Weisburger
Jul 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M G KnizeJ S Felton
May 1, 1994·Epidemiology·L Le MarchandT Hirohata
Oct 6, 1993·Journal of the National Cancer Institute·E GiovannucciW C Willett
Feb 16, 1994·Journal of the National Cancer Institute·P H GannM J Stampfer
Sep 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Skog
Apr 1, 1996·Environmental Health Perspectives·M C AlavanjaA Blair
Dec 16, 1997·International Journal of Cancer. Journal International Du Cancer·M B VeierødD S Thelle
Jul 3, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R SinhaO A Levander
Jul 3, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R SinhaN Rothman
Dec 2, 1999·Journal of the National Cancer Institute·A E NorrishR T Jackson
Oct 6, 2000·Environmental Health Perspectives·G C PrattM J Fenske
Apr 21, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N KazerouniN Rothman
Oct 9, 2001·Epidemiologic Reviews·L N Kolonel
Feb 16, 2002·Journal of the American Dietetic Association·Frances E ThompsonRegina G Ziegler
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·F L MartinD H Phillips
Feb 20, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Susan NowellNicholas P Lang
Feb 3, 2005·Prostate Cancer and Prostatic Diseases·P M RovitoG P Haas
Jun 30, 2005·Molecular Nutrition & Food Research·Rashmi SinhaJoanne Holden
Dec 17, 2005·Cancer Research·Amanda J CrossRashmi Sinha
Apr 5, 2007·American Journal of Industrial Medicine·Anusha KrishnadasanBeate Ritz
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nora L NockBenjamin A Rybicki
Jul 14, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Assieh A MelikianSteven D Stellman
Jul 27, 2007·Journal of Toxicology and Environmental Health. Part a·Byung Mu Lee, Geun Ae Shim

❮ Previous
Next ❯

Citations

Nov 26, 2010·Cancer Causes & Control : CCC·Anja SanderSabine Rohrmann
Oct 6, 2011·Cancer Causes & Control : CCC·Jacqueline M MajorRashmi Sinha
Dec 31, 2011·Cancer Causes & Control : CCC·Amit D JoshiMariana C Stern
Aug 16, 2008·Current Urology Reports·Mark Soloway
Oct 20, 2009·Nutrition and Cancer·Wei Zheng, Sang-Ah Lee
Apr 29, 2011·Nutrition and Cancer·Esther M JohnJocelyn Koo
Jan 15, 2009·Cancer Research·Tram Kim LamMaria Teresa Landi
Jan 1, 2010·The American Journal of Clinical Nutrition·Erin L RichmanJune M Chan
Feb 9, 2016·PeerJ·Qian HeGuang-Lian Xiong
Dec 12, 2012·European Urology·Elizabeth M MaskoStephen J Freedland
Aug 17, 2010·Seminars in Oncology·Todd M GibsonArthur Schatzkin
Jan 19, 2010·Cancer Letters·Naghma KhanHasan Mukhtar
Apr 9, 2010·Meat Science·Lynnette R Ferguson
May 25, 2012·Proteomics·Nisha VermaSimone Schmitz-Spanke
Feb 13, 2013·International Journal of Cancer. Journal International Du Cancer·Deliang TangBenjamin A Rybicki
Jan 4, 2012·Histopathology·Karen S Sfanos, Angelo M De Marzo
Jan 22, 2013·The Prostate·Marni Stott-MillerJanet L Stanford
Aug 3, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasutomo Nakai, Norio Nonomura
Apr 27, 2011·BJU International·Satoshi HoriJohn McLoughlin
Feb 5, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Firew Lemma BerjiaMaarten Nauta
May 23, 2014·The American Journal of Clinical Nutrition·Zaynah AbidRashmi Sinha
May 29, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Lynnette R Ferguson
Dec 16, 2016·BioMed Research International·Somia LassedDjamila Zama
May 26, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Eduardo De StefaniHugo Deneo-Pellegrini
Feb 26, 2020·International Journal of Molecular Sciences·Makoto MatsushitaNorio Nonomura
Apr 17, 2019·Journal of Food and Drug Analysis·Shi-Han JianSung-Fang Chen
Sep 22, 2016·Cancer Prevention Research·Kathryn M WilsonAdam S Kibel
Aug 1, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sabine RohrmannKana Wu
Feb 7, 2021·Nutrients·Michał OczkowskiJoanna Gromadzka-Ostrowska
May 14, 2021·Explore : the Journal of Science and Healing·Marisa DunnMikhail Kogan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.