PMID: 11923584Mar 30, 2002Paper

Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol

Alcoholism, Clinical and Experimental Research
O BlomqvistHenry R Kranzler

Abstract

Central nicotinic cholinergic receptors modify alcohol-induced mesolimbic dopamine activation, which seems to be important in the reinforcing properties of alcohol. Consistent with this model, acute administration to rats of the tertiary nicotinic receptor antagonist mecamylamine blocks both alcohol consumption and alcohol-induced dopamine release in the nucleus accumbens. This study was conducted to test the hypothesis that, during the ascending limb of the blood alcohol concentration curve, mecamylamine would reduce the stimulating and pleasurable effects of an intoxicating dose of alcohol in humans. Ten female and 10 male volunteers with no history of alcohol or substance use disorders, including nicotine dependence, completed the study. During two laboratory sessions, subjects consumed three aliquots of an alcohol-containing drink, with a total ethanol content of 0.7 g/kg (in women) or 0.8 g/kg (in men), over a 30-min period. Two hours before the first drink, subjects were pretreated with mecamylamine or placebo, with the order of sessions counterbalanced. Primary outcome measures included the Drug Effect Questionnaire, the central stimulation subscale of the Alcohol Sensation Scale, and the stimulant subscale of the Biphas...Continue Reading

References

May 1, 1992·Trends in Pharmacological Sciences·G F Koob
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Feb 1, 1987·Alcoholism, Clinical and Experimental Research·H de WitC E Johanson
Feb 1, 1983·British Journal of Pharmacology·P B Clarke, R Kumar
Jul 1, 1983·AJR. American Journal of Roentgenology·G K McLeanD B Freiman
Jan 1, 1980·Behaviour Research and Therapy·S A MaistoV J Adesso
Apr 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P A NewhouseR Lenox
Feb 1, 1994·Drug and Alcohol Dependence·M A Chutuape, H de Wit
Oct 1, 1994·The American Journal of Psychiatry·R M SwiftH Hsuing
Nov 9, 1993·European Journal of Pharmacology·O BlomqvistB Söderpalm
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Feb 1, 1993·Alcoholism, Clinical and Experimental Research·C S MartinR M Swift
Sep 15, 1996·Biological Psychiatry·R M SwiftO Kuznetsov
Nov 22, 1997·European Journal of Pharmacology·O BlomqvistB Söderpalm
Sep 2, 1998·Experimental and Clinical Psychopharmacology·J E RoseE C Westman
Dec 23, 1998·Behavioural Pharmacology·T DukaD N Stephens
Jan 5, 1999·Neurochemistry International·I SzirákiA Lajtha
Jan 12, 1999·Alcoholism, Clinical and Experimental Research·L Holdstock, H de Wit
Mar 4, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M S ReidS P Berger
Mar 4, 2000·Alcoholism, Clinical and Experimental Research·A D LêT K Li
Aug 15, 2000·Behavioural Brain Research·B SöderpalmJ A Engel
Aug 17, 2000·JAMA : the Journal of the American Medical Association·H R Kranzler
Mar 27, 2001·Pharmacology, Biochemistry, and Behavior·J E RoseE C Westman
May 17, 2001·Clinical Therapeutics·J M YoungT P George

❮ Previous
Next ❯

Citations

Apr 28, 2012·Psychopharmacology·Thomas M PiaseckiAndrew C Heath
Jan 22, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Yann Le StratPhilip Gorwood
Jan 18, 2005·Alcoholism, Clinical and Experimental Research·Elizabeth M YoungHarriet de Wit
Jun 4, 2013·Journal of Addiction Medicine·Raye Z LittenUNKNOWN NCIG (National Institute on Alcohol Abuse and Alcoholism Clinical Investigations Group) Study Group
Jun 11, 2008·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Marcelo CruzJerson Laks
May 12, 2006·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Malcolm S ReidJohn Rotrosen
Jul 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Pia SteenslandSelena E Bartlett
Mar 28, 2006·Psychopharmacology·Ashley AchesonHarriet de Wit
Nov 20, 2012·Annual Review of Clinical Psychology·Sherry A McKee, Andrea H Weinberger
Mar 22, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sarah S Dermody, Eric C Donny
Jun 7, 2005·Expert Opinion on Emerging Drugs·Raye Z LittenMark Egli
Jun 29, 2010·Pharmacology, Biochemistry, and Behavior·Pravinkumar S BhutadaDharmendra R Mundhada
Jan 16, 2010·Drug and Alcohol Dependence·Irina EsterlisJulie K Staley
Dec 5, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Cleo L CrunelleWim van den Brink
Jun 9, 2009·Neuropharmacology·Matthew M FordDeborah A Finn
Jul 15, 2009·Drug and Alcohol Dependence·Danilo Antonio BaltieriArthur Guerra de Andrade
Oct 7, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yousef TizabiDavid H Overstreet
May 27, 2003·Alcoholism, Clinical and Experimental Research·Henry Chi, Harriet de Wit
Mar 27, 2009·Alcoholism, Clinical and Experimental Research·Sandra Y RuegerAndrea C King
Feb 22, 2012·Alcoholism, Clinical and Experimental Research·Emma ChildsHarriet de Wit
Apr 19, 2005·Addictive Behaviors·F Joseph McClernon, Jed E Rose
May 3, 2005·European Journal of Pharmacology·Olga D TaraschenkoStanley D Glick
Apr 23, 2013·Pharmacology, Biochemistry, and Behavior·Justin R NickellLinda P Dwoskin
Mar 3, 2009·Biological Psychiatry·Sherry A McKeeErika Balchunas
Aug 7, 2013·Drug and Alcohol Dependence·Jennifer G PlebaniKyle M Kampman
Dec 12, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bruce E Hetzler, Alison M Bauer
Feb 3, 2015·Frontiers in Neuroscience·Shafiqur RahmanRichard L Bell
May 4, 2016·Pharmacology & Therapeutics·Charles P TaylorRae R Matsumoto
Mar 10, 2004·Behavioral and Cognitive Neuroscience Reviews·Thomas H KellyCraig R Rush
Mar 30, 2017·Journal of Psychopharmacology·Walter RobertsSherry A McKee
Oct 28, 2005·Nature Neuroscience·John A Dani, R Adron Harris
Jul 16, 2017·Addiction·Ismene L PetrakisJohn H Krystal
Jul 27, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Anna LarssonJörgen A Engel
Jan 31, 2006·Alcoholism, Clinical and Experimental Research·Dieter J MeyerhoffSara Jo Nixon
Jul 16, 2005·The American Journal on Addictions·David KalmanTony P George
Jan 8, 2009·The Journal of Pharmacology and Experimental Therapeutics·Mia EricsonBo Söderpalm
Jan 4, 2020·Neurochemical Research·Santosh Kumar PrajapatiAlakh N Sahu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.