PMID: 8584248Oct 20, 1995Paper

Mechanical allodynia is more strongly manifested in older rats in an experimental model of peripheral neuropathy

Neuroscience Letters
Y I KimS K Hong

Abstract

Partial peripheral nerve injury often leads to chronic neuropathic pain characterized by symptoms such as allodynia. In the present study, employing a rat model of experimental neuropathy produced by partial denervation of the tail, we examined whether peripheral nerve injury-induced mechanical and thermal allodynia were affected by the animal's age at the time of the injury. The motive of this study was the demonstration in other neuropathy models of the age effects on the manifestation of neuropathic pain symptoms following partial peripheral nerve injury. We compared two groups of young (n = 23, 7-8 weeks old, 150-200 g) and old rats (n = 14, 16-18 months old, 550-800 g). We found that the older rats exhibited more vigorously the behavioral signs of mechanical allodynia during the first week after the nerve injury. With respect to thermal (cold or warm) allodynia, however, we detected no significant difference between young and old rat groups. The results of the present study, as those of previous studies, support the idea that the age at the time of partial peripheral nerve injury affects the severity of certain neuropathic pain symptoms appearing after the injury. However, the present results argue against the suggestion f...Continue Reading

Citations

Mar 8, 2005·The Spine Journal : Official Journal of the North American Spine Society·Wayne H AkesonCholl W Kim
Dec 19, 2000·Neuroscience and Biobehavioral Reviews·L Gagliese, R Melzack
Aug 26, 2003·Advanced Drug Delivery Reviews·Lili X Wang, Zaijie Jim Wang
Feb 16, 2000·Neurobiology of Aging·L Gagliese, R Melzack
May 3, 2012·Pain Research and Treatment·Aldric Hama, Jacqueline Sagen
Apr 25, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Robert P Yezierski
May 24, 2008·Neurobiology of Aging·Uros KovacicFajko F Bajrović
Dec 15, 2006·Pain Practice : the Official Journal of World Institute of Pain·K VissersT Meert
Jan 24, 2006·European Journal of Pain : EJP·Gisèle PickeringAlain Eschalier
Jan 22, 2005·Journal of Neurophysiology·Junichi KitagawaKoichi Iwata
Apr 29, 1998·The Journal of Comparative Neurology·M S Ramer, M A Bisby
Feb 5, 2002·Journal of Neurophysiology·Koichi IwataKenro Kanda
Mar 28, 2009·Annals of Plastic Surgery·Uros KovacicFajko F Bajrović

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