Mechanical and biological properties of Ti-(0-25 wt%)Nb alloys for biomedical implants application

Regenerative Biomaterials
Yuqing ZhangJiang Chen

Abstract

Binary titanium-niobium (Ti-Nb) alloys have recently been attracted due to low Young's moduli and non-toxic properties. This study explores the influence of low Nb content (0-25 wt%) on the comprehensive parameters of tensile stress-strain relationships (ultimate strength (σUTS), yield strength (σ0.2) and elastic modulus (E)), surfaces properties (Vickers microhardness, surface roughness (Ra), water contact angle (WCA), X-ray diffraction (XRD) and scanning electron microscopy (SEM)), corrosion resistance (in artificial saliva and lactic acid) and biological properties (cytotoxicity and alkaline phosphatase activity of MC3T3-E1 pre-osteoblasts) of Ti-xNb alloys (x = 5, 10, 15, 20 and 25 wt%), with using commercially pure grade 2 titanium (cp-Ti) as control. XRD results shown that all the Ti-xNb alloys comprised α + β Ti alloy phases, such that the β phase increased correspondingly with the increased amount of Nb in the alloy, as well as the reduction of E (69-87 GPa). Except Ti-5Nb, all other Ti-xNb alloys showed a significantly higher hardness, increased σUTS and σ0.2, and decreased WCA compared with cp-Ti. No corrosion was detected on Ti-xNb alloys and cp-Ti in artificial saliva and lactic acid solutions. The cytotoxicity of T...Continue Reading

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Citations

Apr 17, 2020·Regenerative Biomaterials·Shuyang ChenJukka P Matinlinna
Apr 27, 2021·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Soham ChowdhuryBidyut Pal

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Methods Mentioned

BETA
X-ray
scanning electron microscopy
protein assay
PCR

Software Mentioned

SPSS

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