PMID: 9165997Apr 1, 1997Paper

Mechanical and material properties of the subchondral bone plate from the femoral head of patients with osteoarthritis or osteoporosis

Annals of the Rheumatic Diseases
B Li, R M Aspden

Abstract

To determine the material properties of the subchondral bone plate in patients with osteoarthritis or osteoporosis. Femoral heads were obtained after surgical removal from age and sex matched groups of patients with either osteoporosis (OP), after a fractured neck of femur, or osteoarthritis (OA) and compared with a normal group. The mechanical stiffness, density, and composition of the subchondral bone plate from sites selected to represent areas of heavy, intermittent, and light loading were measured. Overall, OP bone was the least stiff and dense, followed by OA bone; normal bone was stiffer and more dense (p < 0.05). Though OP bone contained less mineral, the organic and water contents were increased in proportion suggesting no change in the relative amount of organic matrix. OA bone was also hypomineralised (p < 0.05) but had different organic and water fractions suggesting a defect in the matrix. Site variation of most properties was small, though across all the groups the superior region was significantly stiffer than the inferior. This study shows that subchondral bone plate is less stiff than normal in both OP and OA and so cannot, by itself, explain the preserving of the overlying cartilage in OP while aiding its dest...Continue Reading

References

Nov 26, 1979·Calcified Tissue International·S LeesP F Cleary
Nov 1, 1992·Journal of Clinical Pathology·G AmirP A Revell
Dec 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R OettmeierK Abendroth
Nov 1, 1991·Physics in Medicine and Biology·M B Tavakoli, J A Evans
Aug 1, 1991·Annals of the Rheumatic Diseases·C CooperM I Cawley
Jul 1, 1991·Calcified Tissue International·M D GrynpasK P Pritzker
Aug 1, 1991·Calcified Tissue International·C H Turner, M Eich
Oct 1, 1988·Acta Orthopaedica Scandinavica·J BenskeB Tillmann
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W A HodgeR W Mann
May 1, 1972·Journal of Biomechanics·S R SimonR M Rose
Jan 1, 1970·Annals of the Rheumatic Diseases·P D ByersT A Farkas
Jan 1, 1983·Journal of Biomechanics·T D Brown, D T Shaw
Jul 1, 1983·The Journal of the Acoustical Society of America·S LeesM Leonard
Apr 1, 1982·Annals of the Rheumatic Diseases·L SolomonJ P Browett

❮ Previous
Next ❯

Citations

Jan 2, 2004·Aging Clinical and Experimental Research·Jan DequekerFrank P Luyten
Oct 20, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Henning MadryAndrea Facchini
Oct 17, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Yoshinori IshiiShin-ichi Toyabe
Sep 23, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z-M ZhangL-Y Dai
Dec 14, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W-J JinL-Y Dai
Aug 14, 2012·Journal of Bone and Mineral Metabolism·Ana Maria RodriguesHelena Canhão
Mar 17, 2012·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Harrie Weinans
Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J S DayH Weinans
May 23, 2008·Rheumatology·R M Aspden
May 20, 2003·Journal of Biomechanical Engineering·L P LiA Shirazi-Adl
Sep 8, 2010·Journal of Biomechanical Engineering·Mack G Gardner-MorseMaria L Roemhildt
Sep 19, 2009·Annals of the Rheumatic Diseases·Tuhina NeogiDavid Felson
Dec 6, 1997·Annals of the Rheumatic Diseases·D Hamerman
Jan 18, 2002·Annals of the Rheumatic Diseases·J P A ArokoskiH Kröger
Oct 26, 2012·Computational and Mathematical Methods in Medicine·Donald D AndersonJohn A Lynch
Aug 4, 2012·Therapeutic Advances in Musculoskeletal Disease·Tuhina Neogi
Feb 14, 2008·BMC Musculoskeletal Disorders·Yvonne H SniekersSimon C Mastbergen
Nov 4, 2009·Arthritis Research & Therapy·Martha C Castaño BetancourtJan H Waarsing
Apr 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G HilalD Lajeunesse
Aug 30, 2008·Regenerative Medicine·L A McMahonP J Prendergast
Feb 2, 2010·The Review of Scientific Instruments·N GuzelsuS P Kotha
Nov 8, 2013·Journal of Bone and Mineral Metabolism·Gun-Il Im, Min-Kyu Kim
Mar 7, 2006·Current Rheumatology Reports·Johanne Martel-PelletierJean-Pierre Pelletier
Dec 1, 2010·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·N Espinosa, G Klammer
Nov 11, 2008·Connective Tissue Research·Carl Alex DePaulaNejat Guzelsu
Jan 18, 2016·Osteoarthritis and Cartilage·Ifaz HaiderHanspeter Frei
Oct 5, 2010·Seminars in Arthritis and Rheumatism·Pietro Enea LazzeriniFranco Laghi-Pasini
Dec 9, 2008·The Medical Clinics of North America·Kenneth D BrandtEric Radin
Dec 9, 2008·The Medical Clinics of North America·Steven R Goldring
Aug 9, 2008·Rheumatic Diseases Clinics of North America·Kenneth D BrandtEric L Radin
Aug 9, 2008·Rheumatic Diseases Clinics of North America·Steven R Goldring
Apr 27, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Milena FiniRoberto Giardino

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.