Mechanical and microstructural investigation of the cyclic behavior of human amnion

Journal of Biomechanical Engineering
Michela PerriniE Mazza

Abstract

The structural and mechanical integrity of amnion is essential to prevent preterm premature rupture (PPROM) of the fetal membrane. In this study, the mechanical response of human amnion to repeated loading and the microstructural mechanisms determining its behavior were investigated. Inflation and uniaxial cyclic tests were combined with corresponding in situ experiments in a multiphoton microscope (MPM). Fresh unfixed amnion was imaged during loading and changes in thickness and collagen orientation were quantified. Mechanical and in situ experiments revealed differences between the investigated configurations in the deformation and microstructural mechanisms. Repeated inflation induces a significant but reversible volume change and is characterized by high energy dissipation. Under uniaxial tension, volume reduction is associated with low energy, unrecoverable in-plane fiber reorientation.

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Citations

Dec 25, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Arabella MauriEdoardo Mazza
Mar 19, 2016·Journal of the Mechanical Behavior of Biomedical Materials·R HopfA E Ehret
Aug 10, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Michela PerriniMartin Ehrbar
Oct 27, 2015·Biomechanics and Modeling in Mechanobiology·Arabella MauriEdoardo Mazza
Sep 8, 2016·Nature Reviews. Urology·Carla M J MuytjensEleftherios P Diamandis
Oct 19, 2017·Nature Communications·Alexander E EhretEdoardo Mazza
Nov 14, 2017·Journal of Biomechanical Engineering·R C PicuM R Islam
Jun 21, 2016·Journal of Biomechanical Engineering·Kevin BircherEdoardo Mazza
May 1, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lauren RichardsonRamkumar Menon
Sep 6, 2019·Interface Focus·Kevin BircherEdoardo Mazza
May 21, 2020·Biomedizinische Technik. Biomedical Engineering·Arash Dadkhah, Ata Hashemi
Jul 23, 2020·Frontiers in Physiology·Lauren RichardsonArum Han
Jul 10, 2018·The American Journal of Pathology·Lauren Richardson, Ramkumar Menon
Sep 25, 2017·The American Journal of Pathology·Lauren S RichardsonRamkumar Menon

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