Mechanical behavior comparison of spider and silkworm silks using molecular dynamics at atomic scale

Physical Chemistry Chemical Physics : PCCP
Myeongsang LeeSungsoo Na

Abstract

Spider and silkworm silk proteins have received much attention owing to their inherent structural stability, biodegradability, and biocompatibility. These silk protein materials have various mechanical characteristics such as elastic modulus, ultimate strength and fracture toughness. While the considerable mechanical characteristics of the core crystalline regions of spider silk proteins at the atomistic scale have been investigated through several experimental techniques and computational studies, there is a lack of comparison between spider and silkworm fibroins in the atomistic scale. In this study, we investigated the differences between the mechanical characteristics of spider and silkworm fibroin structures by applying molecular dynamics and steered molecular dynamics. We found that serine amino acids in silkworm fibroins not only increased the number of hydrogen bonds, but also altered their structural characteristics and mechanical properties.

References

Feb 1, 1996·Journal of Molecular Graphics·W HumphreyK Schulten
May 26, 1999·International Journal of Biological Macromolecules·C Y HayashiR V Lewis
Apr 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thomas ScheibelSusan L Lindquist
Oct 14, 2005·Journal of Computational Chemistry·James C PhillipsKlaus Schulten
Jun 4, 2010·Journal of the Royal Society, Interface·Sinan Keten, Markus J Buehler
Aug 2, 2011·Nature Nanotechnology·Tuomas P J Knowles, Markus J Buehler
Oct 25, 2011·Biopolymers·Graham Bratzel, Markus J Buehler
Feb 18, 2014·Nanotechnology·Max Solar, Markus J Buehler
Mar 7, 2014·Acta Crystallographica. Section C, Structural Chemistry·Estelle MossouV Trevor Forsyth
Mar 25, 2014·Nature Materials·Allen Y ChenTimothy K Lu
May 3, 2014·Journal of the Royal Society, Interface·Yuan ChengYong-Wei Zhang
Jul 30, 2014·Physical Chemistry Chemical Physics : PCCP·J I KimS Na
Nov 27, 2014·Physical Chemistry Chemical Physics : PCCP·Bumjoon ChoiKilho Eom
Dec 9, 2014·Biophysical Chemistry·Juan Francisco Carrascoza MayenRadu Silaghi-Dumitrescu
Jun 4, 2015·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Hyun Joon ChangSungsoo Na
Sep 19, 2015·Biochemical and Biophysical Research Communications·Myeongsang LeeSungsoo Na

❮ Previous
Next ❯

Citations

Aug 16, 2016·International Journal of Molecular Sciences·Marlene AnderssonAnna Rising
Feb 24, 2017·ACS Applied Materials & Interfaces·Qing TuStefan Zauscher
Feb 6, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Hyunsung ChoiSungsoo Na
Jun 15, 2016·Journal of Biomaterials Applications·Zhaozhu ZhengDavid Kaplan
Apr 27, 2017·Journal of Biomolecular Structure & Dynamics·Yoonjung KimSungsoo Na
Mar 21, 2018·Physical Chemistry Chemical Physics : PCCP·Myeongsang LeeKilho Eom
Mar 13, 2020·Frontiers in Plant Science·Congyue Annie PengWilliam R Marcotte
Jul 23, 2020·Frontiers in Chemistry·Aleksandra P KiselevaElena F Krivoshapkina

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Biotechnology
Hannah ChungSang Yup Lee
International Journal of Peptide and Protein Research
M W PanditM S Rao
Die Naturwissenschaften
Y Asano, H Sinohara
Advances in Protein Chemistry
F LUCASS G SMITH
© 2021 Meta ULC. All rights reserved