Mechanical cell injury

Annals of the New York Academy of Sciences
K A Barbee

Abstract

The tissues of the body are continually subjected to mechanical stimulation by external forces, such as gravity, and internally generated forces, such as the pumping of blood or muscle contraction. Within a physiological range, the forces elicit adaptive responses acutely (to rapidly alter function) and chronically (to remodel tissue structure to optimize load-bearing capabilities). When the forces exceed certain thresholds, injury results. To understand the mechanisms of mechanical injury at the cellular level, we must analyze the structural response of the cell to various modes of deformation and examine the biological consequences of the structural alterations caused by the trauma. This chapter reviews the mechanics of cell membrane deformation and failure. Evidence for the strain-rate-dependent, transient disruption of cell membranes, or mechanoporation, is presented for a variety of cell types. The complex interactions between the structural damage and the biological sequelae are illustrated using clinically relevant forms of cell injury. Finally, novel therapeutic approaches targeting membrane integrity are described.

References

Jun 1, 1976·Biophysical Journal·E A EvansL Melnik
Aug 1, 1992·Journal of Biomechanical Engineering·J L WilliamsD M Belloli
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R C LeeR L Wollmann
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·V Lindner, M A Reidy
Nov 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J FingerleM A Reidy
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M FechheimerS G Zimmer
May 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M Klagsbrun, E R Edelman
Jul 1, 1989·Journal of Applied Physiology·F K WinstonL E Thibault
May 1, 1989·Basic Research in Cardiology·P C Dartsch, E Betz
Feb 18, 1972·Science·S J Singer, G L Nicolson
Apr 1, 1984·The Journal of Cell Biology·P L McNeilD L Taylor
Nov 24, 1995·Science·Z XiaM E Greenberg
Jun 1, 1995·Circulation Research·M S ClarkeP L McNeil
Sep 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J L SchafferM L Gray
Jan 1, 1994·Annals of Biomedical Engineering·K A BarbeeL E Thibault
Feb 1, 1993·Journal of Biomechanical Engineering·J A GalbraithD R Matteson
Jun 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H C HerrmannE S Barnathan
Mar 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M S Clarke, D L Feeback
Apr 7, 1997·The Journal of Cell Biology·P L McNeil, R A Steinhardt
May 7, 1998·Annals of Biomedical Engineering·B MorrisonT K McIntosh
May 20, 1998·The Journal of Surgical Research·F A MerchantM Toner
Aug 10, 2000·Radiation Research·J HannigR C Lee
Nov 4, 2000·Journal of Neurotrauma·R RaghupathiT K McIntosh
Apr 9, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J D MarksR C Lee
Jul 31, 2001·Journal of Biomechanical Engineering·D M Geddes, R S Cargill
Feb 28, 2002·Biophysical Journal·Stacey A MaskarinecKa Yee C Lee
Dec 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kathryn E SaatmanDavid F Meaney
Jun 1, 1963·Journal of Cellular and Comparative Physiology·R P RAND, A C BURTON
Apr 1, 1952·The Journal of Physiology·A L HODGKINB KATZ

❮ Previous
Next ❯

Citations

Mar 6, 2009·Journal of Neurotrauma·Crystal M SimonMichelle C LaPlaca
Sep 1, 2009·Tissue Engineering. Part C, Methods·Minggan LiXiongbiao Chen
Jul 15, 2011·Artificial Organs·Ming G LiXiongbiao Chen
Apr 29, 2011·American Journal of Physiology. Cell Physiology·Moonsun HwangJianjie Ma
Aug 19, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Edward FelderPaul Dietl
Apr 1, 2014·Clinical Proteomics·Sean ShenJoseph A Loo
Apr 19, 2011·Journal of Bioscience and Bioengineering·Annalisa TirellaArti Ahluwalia
Oct 9, 2009·Journal of Biomechanics·Michelle C Laplaca, Gustavo R Prado
Jun 24, 2008·Experimental Neurology·Devrim KilincKenneth A Barbee
Jun 13, 2015·Scientific Reports·Jan HendriksMarcel Karperien
Jan 31, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L D BlechaD P Pioletti
Jul 13, 2016·Ultrasound in Medicine & Biology·Eli VlaisavljevichZhen Xu
Aug 18, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Julia HalfordIna-Beate Wanner
Jan 5, 2014·Journal of Biomechanical Engineering·David F MeaneyCameron Dale Bass
Sep 20, 2007·Biotechnology and Bioengineering·Daniel M HallowMark R Prausnitz
Jun 13, 2006·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Verna Hendricks-Ferguson
Dec 8, 2006·Archives of Dermatological Research·Justyna Niderla-BielińskaStanisław Moskalewski
Oct 17, 2018·Cell Death Discovery·Arada VinaiphatVisith Thongboonkerd
Oct 16, 2019·Biointerphases·Sudipto DattaPallab Datta
May 13, 2014·Biological & Pharmaceutical Bulletin·Kazunori ShimizuSatoshi Konishi
May 14, 2016·BMB Reports·Tao TanJianjie Ma
Oct 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·MyungGu Yeo, GeunHyung Kim
Jul 16, 2020·Scientific Reports·Mohammad Nooranidoost, Ranganathan Kumar
Dec 8, 2021·Soft Matter·Christina M CaragineAlexandra Zidovska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.