Mechanical characterization and drug permeation properties of tetracaine-loaded bioadhesive films for percutaneous local anesthesia

Drug Development and Industrial Pharmacy
G P MossD F McCafferty

Abstract

In the development of bioadhesive patch devices for percutaneous local anesthesia, the tensile properties of the films produced after the casting of the gel intermediates is of key importance to the clinical compliance of the product, and its effective delivery of the local anesthetic agent. A range of bioadhesive patches were formulated and their mechanical and in vitro permeation properties determined. Altering formulation significantly altered the mechanical properties of films. The tensile properties of the films could be modified to allow concomitant benefits in the mechanical and drug permeation properties of the films, ensuring that patches not only exerted clinically beneficial effects, but are also mechanically robust. Tetracaine was found to plasticize films and while this effect was weak, it was significant both statistically and potentially also in the effect it has on the clinical use of these devices. Drug release from tetracaine patches demonstrate the same trends as found previously across polydimethylsiloxane films. By altering the formulation of the patch device, the drug release from the device to the skin is readily and accurately controlled, and was not solely a function of the stratum corneum barrier prope...Continue Reading

References

Jan 1, 1989·British Journal of Anaesthesia·D F McCaffertyV Boston
Apr 1, 1974·Journal of Pharmaceutical Sciences·G L FlynnT J Roseman
Jun 1, 1993·Pharmaceutical Research·N H ParikhB D Rohera
Sep 1, 1993·British Journal of Anaesthesia·D F McCafferty, A D Woolfson
Apr 1, 1997·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S C Russell, E Doyle
May 24, 2000·British Journal of Anaesthesia·D F McCaffertyG P Moss
Nov 16, 2002·International Journal of Pharmaceutics·Louise J TaylorGary P Moss
Jul 6, 2004·International Journal of Pharmaceutics·Andrew C DennisGary P Moss

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Citations

Oct 20, 2010·International Journal of Molecular Sciences·Heidi M MansourPatrick P Deluca
Mar 24, 2018·Scientific Reports·Kajal GhosalIvo Provaznik

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